Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span
By A. Misharin, Luisa Morales-Nebreda, P. Reyfman, C. Cuda, J. Walter, Alexandra McQuattie-Pimentel, Ching‐I Chen, K. R. Anekalla, N. Joshi, Kinola J. N. Williams and 33 more. Journal of Experimental Medicine, 2017
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Little is known about the relative importance of monocyte and tissue-resident macrophages in the development of lung fibrosis. We show that specific genetic deletion of monocyte-derived alveolar macrophages after their recruitment to the lung ameliorated lung fibrosis, whereas tissue-resident alveolar macrophages did not contribute to fibrosis. Using transcriptomic profiling of flow-sorted cells, we found that monocyte to alveolar macrophage differentiation unfolds continuously over the course of fibrosis and its resolution. During the fibrotic phase, monocyte-derived alveolar macrophages differ significantly from tissue-resident alveolar macrophages in their expression of profibrotic genes. A population of monocyte-derived alveolar macrophages persisted in the lung for one year after the resolution of fibrosis, where they became increasingly similar to tissue-resident alveolar macrophages. Human homologues of profibrotic genes expressed by mouse monocyte-derived alveolar macrophages during fibrosis were up-regulated in human alveolar macrophages from fibrotic compared with normal lungs. Our findings suggest that selectively targeting alveolar macrophage differentiation within the lung may ameliorate fibrosis without the adverse consequences associated with global monocyte or tissue-resident alveolar macrophage depletion.
Subfields: Molecular Biology, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/eae71caff103a405921f0943f84fc044790b12bc
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Citations in the corpus
- Human Monocyte Subsets and Phenotypes in Major Chronic Inflammatory Diseases (2019, result): “This was shown in IPF patients where alveolar macrophages expressed a gene signature similar to that of monocyte-derived macrophages of bleomycin-treated animals (120).”
- Diversity, Mechanisms and Significance of Macrophage Plasticity (2019, background): “In different contexts—including tissue repair and response to pathogens mediated by type 1 or type 2 immunity—macrophages activated by IL-4 or IL-13, in concert with other environmental cues, orchestrate repair, remodeling, and fibrosis (102, 103, 116, 117).”