An intrinsic mechanism of corticogenesis from embryonic stem cells

By N. Gaspard, T. Bouschet, R. Hourez, J. Dimidschstein, G. Naeije, J. Ameele, I. Espuny-Camacho, Adèle Herpoel, Lara Passante, S. Schiffmann and 2 more. Nature, 2008

652 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/79fdc3cf4159245237618ffc488390d3c513bc45

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Citations in the corpus

Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals. (2008, background): “tance (one to several millimeters; Garaschuk et al., 2000; Adelsberger et al., 2005).”
The Glial Nature of Embryonic and Adult Neural Stem Cells (2009, background): “Stem cells in culture can even sequentially produce subtypes of neurons over time whose identities match the layer-specific temporal pattern observed in vivo (Gaspard et al. 2008).”
A census of human transcription factors: function, expression and evolution (2009, background): “Ultimately, it might be possible to predict how the actions of different regulators lead to particular outcomes, and to apply these predictions in clinical settings, such as directing the progression of stem cell differentiatio”
Developmental genetics of vertebrate glial–cell specification (2010, background): “This developmental program is largely cell-intrinsic, because cultured neural progenitors derived from the embryonic CNS, as well as embryonic-stem-cell-derived neural progenitors, generate neuron subtypes in a precise temporal and laminar orde”
Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditions. (2012, result): “In the absence of positional cues, the progenitors defaulted into an anterior neural identity similar to what has been reported for other ES differentiation paradigms (Gaspard et al., 2008; Li et al., 2009; Pankratz et al., 2007).”
Organogenesis in a dish: Modeling development and disease using organoid technologies (2014, background): “These include the production of intermediate progenitor types, as well as the timed production of layer identities similar to those in vivo (50).”
Modeling Hippocampal Neurogenesis Using Human Pluripotent Stem Cells (2014, methodology): “In addition, we applied cyclopamine, an antagonist of the Sonic Hedgehog pathway, to enrich for dorsal forebrain progenitors (Gaspard et al., 2008) (Figure 1A).”
Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses (2012, background): “Mouse ES cells have been shown to be competent to differentiate to cerebral cortex neurons in vitro”