Embryonic stem cells differentiate into oligodendrocytes and myelinate in culture and after spinal cord transplantation.

By Su-juan Liu, Yun Qu, Todd J. Stewart, M. Howard, S. Chakrabortty, T. Holekamp, J. Mcdonald. Proceedings of the National Academy of Sciences of the United States of America, 2000

606 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/786a5b7d004e1e209395534e0d525a794a04fcc8

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In Cellular and Molecular Neuroscience

1. G. Keller

In Developmental Neuroscience

1. Austin G Smith
2. G. Keller
3. Kenneth R. Boheler
4. A. Wobus

In Molecular Biology

1. G. Keller
2. Kenneth R. Boheler
3. A. Wobus
4. Austin G Smith
5. Richard A. Young
6. Jennifer Nichols
7. Qi-Long Ying
8. S. Yamanaka

Citations in the corpus

• β-Catenin signaling is required for neural differentiation of embryonic stem cells (2004, background): “In successful transplantation studies, ES cells are predifferentiated into the desired cell types, which may then integrate into the transplanted tissue (Brustle et al., 1999; Chen and Mok, 1995; Dinsmore et al., 1996; Liu et al., 2000).”
• Neural stem cells constitutively secrete neurotrophic factors and promote extensive host axonal growth after spinal cord injury. (2003, background): “Recently it has been reported that embryonic stem cell grafts to the spinal cord promote functional recovery after injury (McDonald et al., 1999) and that one potential mechanism of this beneficial effect may be reduction of demyelination (Liu et al., 2000).”
• Embryonic stem cell differentiation: emergence of a new era in biology and medicine. (2005, result): “…remyelination of the damaged nerves may have played some role, as a later study demonstrated that ES-cell-derived neural cells transplanted into spinal cords of rats with chemically induced demyelination preferentially differentiate into oligoendrocytes and myelinated host axons (Liu et al. 2000).”
• Embryo-derived stem cells: of mice and men. (2001, background): “In adults, transplantation of glial derivatives of ES cells results in a degree of remyelination in a rat model of multiple sclerosis (Brustle et al. 1999) and, most dramatically, to a partial functional recovery in a spinal cord injury model (Liu et al. 2000).”
• Embryonic stem cells: prospects for developmental biology and cell therapy. (2005, background): “(95), while oligodendrocytes myelinated host axons after transplantation that could partially restore function in rodents with spinal cord injury (211, 225).”