Mood disorders and allostatic load.

By Bruce S. McEwen. Biological Psychiatry, 2003

1,121 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Biological Psychiatry, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/7850945c5b9996b346420c36c834e04395b105cc

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Behavioral Neuroscience

1. Bruce S. McEwen
2. J. Wingfield
3. Keith Bredemeier
4. J. Koolhaas
5. A. Beck
6. S. Korte
7. B. Casey
8. C. Hammen

In Biological Psychiatry

1. J. Wingfield
2. A. Beck
3. Keith Bredemeier
4. C. Hammen
5. B. Casey
6. J. Koolhaas
7. S. Korte
8. Bruce S. McEwen

In Developmental Neuroscience

1. J. Wingfield
2. A. Beck
3. Keith Bredemeier
4. C. Hammen
5. J. Koolhaas
6. S. Korte
7. Conor Liston
8. Frank J. Farach

Citations in the corpus

• Limbic-frontal circuitry in major depression: a path modeling metanalysis (2004, background): “In keeping with recent theories of dysregulated homeo - static responses to ongoing stress ( McEwen , 2003 ; McEwen and Wingfield , 2003 ) , the more restricted fronto - frontal abnormalities in the CBT group may reflect a preserved compensatory capacity not seen in patients requiring medication…”
• Stress and depression: old questions, new approaches (2015, background): “The impact of cumulative stress, especially measured as allostatic load, has also been the focus of efforts to understand depression and other forms of dysfunctional behavioral and medical health [13].”
• Behavior Problems After Early Life Stress: Contributions of the Hippocampus and Amygdala (2014, background): “McEwen (76) noted parallels between these findings and patterns of brain alterations in humans during initial episodes of major depression,”
• Glucocorticoids, depression, and mood disorders: structural remodeling in the brain. (2005, background): “In Cushing’s disease, there are depressive symptoms that can be relieved by surgical correction of the hypercortisolemia [6].”
• A Unified Model of Depression (2016, positive): “Over time, elevated cortisol can lead to neural atrophy (mediated by glutamate, and particularly in the hippocampus;5 see McEwen, 2003; Sapolsky, 2000) that could further exacerbate HPA dysregulation (as the hippocampus plays a key role in HPA feedback inhibition; see Mahar, Bambico, Mechawar, &…”
• Sleep deprivation as a neurobiologic and physiologic stressor: Allostasis and allostatic load. (2006, background): “In Cushing’s disease, there are depressive symptoms that can be relieved by surgical correction of the hypercortisolemia [10].”
• The Darwinian concept of stress: benefits of allostasis and costs of allostatic load and the trade-offs in health and disease. (2005, background): “As a result, the effects of the different mediators on target cells are prolonged and may produce receptor changes [233,234].”
• Psychosocial stress reversibly disrupts prefrontal processing and attentional control (2009, background): “When susceptible individuals are exposed to repeated, chronic stress, by contrast, impairments in PFC-mediated flexibility may persist, counteracting short-term benefits in a way that may ultimately contribute to the diverse symptomatology of chronic stress-related neuropsychiatric diseases (2, 39).”