Faculty Opinions recommendation of Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context.

By R. Moon. 2006

350 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Towards an integrated view of Wnt signaling in development (2009, background): “Indeed, Wnt5A is able to induce signaling through β-catenin/TCF in cells of the human 293 embryonic kidney cell line that express Fz4 and LRP5 (Mikels and Nusse, 2006).”
INTERNATIONAL UNION OF BASIC AND CLINICAL PHARMACOLOGY REVIEW WNT/Frizzled signalling: receptor-ligand selectivity with focus on FZD-G protein signalling and its physiological relevance: IUPHAR Review 3 (2014, unknown): “Further, WNT-5A triggers β-catenin signalling in HEK294/FZD4 cells, a response that can be inhibited when it is co-transfected with the receptor ROR2 (Mikels and Nusse, 2006).”
Function and biological roles of the Dickkopf family of Wnt modulators (2006, background): “Comparing Dkk1 to dominant-negative Lrp6 or to other receptor antagonists such as Wise may reveal Lrp6-independent functions of Dkks. JNK activation may be one such b-catenin-independent effect of blocking Wnt-LRP6 signaling.”
Wnt/beta-catenin signaling in development and disease. (2006, unknown): “pathway, although paradoxically Wnt5a can also activate the canonical pathway by directly engaging Fz4 (Mikels and Nusse, 2006) and Fz5 (He et al.”