CRISPR-Cas systems in bacteria and archaea: versatile small RNAs for adaptive defense and regulation.

By Devaki Bhaya, M. Davison, Rodolphe Barrangou. Annual Review of Genetics, 2011

908 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/2d5cb07d38d1aaae853b9187b1d325991e684ebf

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Citations in the corpus

RNA-Guided Human Genome Engineering via Cas9 (2013, background): “Bacterial and archaeal clustered regularly interspaced short palindromic repeats (CRISPR) systems rely on CRISPR RNAs (crRNAs) in complex with CRISPR-associated (Cas) proteins to direct degradation of complementary sequences present within invading viral and plasmid DNA (1-3).”
Pseudomonas aeruginosa Lifestyle: A Paradigm for Adaptation, Survival, and Persistence (2017, background): “…which results in the initiation of the cleavage of the crRNA–foreign DNA hybridization complex, mediating survival of bacteria after viral infections while protecting themselves from lysis (Brouns et al., 2008; Mojica et al., 2009; Deveau et al., 2010; Garneau et al., 2010; Bhaya et al., 2011).”
Genome Engineering Using the CRISPR Cas9 System (2019, background): “The second stage which is the recognition stage occurs when the phage attack or inject it’s DNA for the second time into the host cell (Bacteria or Archaea), the host CRISPR loci transcribed it spacers into small form of non-coding RNA known as Pre-CRISPR RNA which link up through base pairing with ”
Genome Editing—Principles and Applications for Functional Genomics Research and Crop Improvement (2017, background): “The spacers (typically 21–72 bp) are derived from invading viral or plasmid DNA and can guide Cas9 to cleave an invading protospacer, the sequence in the foreign genome from which spacers are derived, on subsequent invasion by viruses or plasmids (Horvath and Barrangou, 2010; Bhaya et al., 2011).”
Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems (2013, background): “The Cas9 gene, from the type II bacterial CRISPR system of Streptococcus pyogenes, complexes with a designer genome targeting CRISPR guide RNA (gRNA) to determine the site specificity of the DNA cutting activity (2,3) (Figure 1A).”
RNA-programmed genome editing in human cells (2013, background): “Research into genome defense mechanisms in bacteria showed that CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)/Cas (CRISPR-associated) loci encode RNA-guided adaptive immune systems that can destroy foreign DNA (Bhaya et al., 2011; Terns and Terns, 2011; Wiedenheft et al., 2012).”
Proteins and DNA elements essential for the CRISPR adaptation process in Escherichia coli (2012, background): “The inverse process of spacer acquisition—spacer deletion—probably occurs through recombination or slippage of theDNApolymerase during replication and requires at least two repeats (10,23).”
CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes (2013, positive): “Prokaryotes have evolved diverse RNA-mediated systems that use short CRISPR RNAs (crRNAs) and Cas (CRISPR-associated) proteins to detect and defend against invading DNA elements (Bhaya et al., 2011; Marraffini and Sontheimer, 2008, 2010; Wiedenheft et al., 2012).”