The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype

By Sheng Zhou, J. Schuetz, K. Bunting, A. Colapietro, J. Sampath, J. J. Morris, I. Lagutina, G. Grosveld, M. Osawa, H. Nakauchi and 1 more. Nature Medicine, 2001

2,403 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/779d00aaa3d19eabadabbdcd337e5b87ff750c49

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In Genetics

1. M. Clarke
2. M. Wicha
3. G. Dontu
4. Kyle W. Jackson
5. M. Kawamura
6. W. Abdallah
7. Catriona H. M. Jamieson
8. Derrick J. Rossi

In Molecular Biology

1. Elaine Fuchs
2. C. Blanpain
3. Irving L. Weissman
4. M. Wicha
5. M. Clarke
6. Derrick J. Rossi
7. G. Dontu
8. Catriona H. M. Jamieson

In Oncology

1. M. Wicha
2. M. Clarke
3. G. Dontu
4. Irving L. Weissman
5. J. Green
6. Elaine Fuchs
7. G. J. Yoshida
8. Grant A. Challen

Citations in the corpus

• Metabolic reprogramming: the emerging concept and associated therapeutic strategies (2015, background): “Mechanistically, the cytosolic domain of ENPP1 is crucial for interaction with ABCG2 at the cellular membrane; thus ENPP1 contributes to drug resistance by promoting the stabilization of ABCG2 [86, 87].”
• Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche. (2004, background): “(Martin et al., 2002; Watt, 2002), it was evident that, although many bulge LRCs contacted this SCs (Barrandon and Green, 1987).”
• Mechanisms of chemoresistance in cancer stem cells (2013, background): “ABCG2 is found in milk ducts of the mammary gland, hematopoietic stem cells and the blood brain barrier [27-29].”
• Differences between human and mouse embryonic stem cells. (2004, background): “194720 F: GTTTATCCGTGGTGTGTCTGG (Zhou et al., 2001) R: GGGCCACATGATTCTTCCAC R: CTGAGCTATAGAGGCCTGGG Cx 43 Mm.”
• Stems cells and the pathways to aging and cancer. (2008, background): “For instance, stem cells from a variety of tissues express high levels of ABC transporter proteins that are known to have physiological roles in cytoprotection through their capacity to actively pump genotoxic and xenobiotic compounds out of the cell (Zhou et al., 2001).”
• Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation (2010, background): “Bcrp is prominently expressed in stem cells from various sources, including bone marrow and skeletal muscle (Zhou et al., 2001).”
• Distinct Hematopoietic Stem Cell Subtypes Are Differentially Regulated by TGFβ1 (2010, positive): “…SP results from differential efflux of the dye by HSCs because of high multi-drug-resistance (MDR)-type transporter activity (Goodell et al., 1996; Zhou et al., 2001), it will be interesting to determine whether the discrete efflux properties will prove to have biological significance for the HSC…”