LDL-receptor-related proteins in Wnt signal transduction

By K. Tamai, Mikhail V. Semenov, Y. Kato, Rebecca Spokony, Chunming Liu, Y. Katsuyama, Fred J Hess, J. Saint-jeannet, Xi He. Nature, 2000

1,422 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/775c355f8bc120fc30e4d0f674a84a45566c45af

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Hans Clevers
2. R. Nusse
3. Christof Niehrs
4. Fanxin Long
5. K. Willert
6. A. Gregorieff
7. S. Angers
8. Z. Steinhart

In Molecular Biology

1. Hans Clevers
2. R. Nusse
3. Christof Niehrs
4. K. Guan
5. Xi He
6. Fanxin Long
7. K. Willert
8. S. Angers

Citations in the corpus

• Signalling in neural development: WNTS in the vertebrate nervous system: from patterning to neuronal connectivity (2005, background): “fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=16974">LRP6 — single-pass transmembrane proteins — is specifically required for signalling through the canonical pathwa”
• An LDL-receptor-related protein mediates Wnt signalling in mice (2000, background): “and by overexpression of LRP6 in Xenopus embryo”
• Wnt signaling in the intestinal epithelium: from endoderm to cancer. (2005, background): “Wnts activate responding cells by interacting with the seven-span transmembrane protein Frizzled (Fz) and the single-span transmembrane protein LRP (Bhanot et al. 1996; Pinson et al. 2000; Tamai et al. 2000; Wehrli et al. 2000).”
• Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum: an entero-bone endocrine axis (2008, background): “Lrp5 is a member of the family of lipoprotein receptor related proteins (Lrps), a small group of single-pass transmembrane proteins (Tamai et al., 2000).”
• α4β1- and α6β1-integrins are functional receptors for midkine, a heparin-binding growth factor (2004, methodology): “The coding sequences of human β1-integrin (Argraves et al., 1987) and human α6-integrin (Tamura et al., 1990) were ligated into an expression vector pcDNA3.”
• Sclerostin Mediates Bone Response to Mechanical Unloading Through Antagonizing Wnt/β‐Catenin Signaling (2009, background): “(20) In addition, sclerostin protein expression was relatively restricted in bone postnatally, unlike Lrp5.”
• Secreted antagonists of the Wnt signalling pathway (2003, background): “…a member of the frizzled (Fz) family (there are 10 of these seven-transmembrane-span proteins in humans) and either one of two single-span transmembrane proteins, low-density-lipoprotein-receptorrelated proteins [LRP-5 and LRP-6 (Pinson et al., 2000; Tamai et al., 2000; Wehrli et al., 2000)] (Fig.”
• Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q. (2004, background): “Consistent with this notion, LRP5 has been shown to interact with different Wnt/frizzled complexes (Tamai et al. 2000; Semënov et al. 2001; Kato et al. 2002; Caricasole et al. 2003), although the binding sites have not been determined.”
• Nucleo-cytoplasmic distribution of β-catenin is regulated by retention (2006, methodology): “, 1996) and LRP5/6 (Pinson et al., 2000; Tamai et al., 2000), this destruction complex is inactivated, which leads to accumulation of -catenin in the cytoplasm and its entry into the nucleus.”