Stretching Single Talin Rod Molecules Activates Vinculin Binding

By A. del Rio, R. Perez-Jimenez, Ruchuan Liu, Pere Roca-Cusachs, Julio M. Fernandez, M. Sheetz. Science, 2009

1,477 citations recorded by the source corpus.

Subfields: Atomic and Molecular Physics, and Optics, Cell Biology

View Paper: https://www.semanticscholar.org/paper/76ca2007c250e6ff67856b4fe2cf9f721c81cbff

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In Atomic and Molecular Physics, and Optics

In Cell Biology

Citations in the corpus

The myofibroblast: paradigm for a mechanically active cell. (2010, background): “…of FA proteins bear the structural potential to act as mechanical switch like integrins (Arnaout et al., 2005; Luo et al., 2007), vinculin (Cohen et al., 2006; Ziegler et al., 2006), talin (del Rio et al., 2009; Gingras et al., 2006), Src (Wang et al., 2005), and p130CAS (Sawada et al., 2006).”
Extracellular matrix: a dynamic niche component during cancer progression (2012, neutral): “Many of the focal adhesion components, including talin and p130Cas, undergo conforma tional changes that impart functional consequences in response to applied force (Sawada et al., 2006; del Rio et al., 2009; Wang et al., 2011).”
Integrins and extracellular matrix in mechanotransduction. (2010, background): “Vinculin recruitment has now been attributed to the fact that vinculin-binding sites in the talin tail domain are concealed within bundles ofa helices, which can open under tension (del Rio et al. 2009; Campbell and Humphries 2010).”
Intrinsic extracellular matrix properties regulate stem cell differentiation. (2010, background): “A variety of mechanisms for this process have been proposed including (1) force-sensitive protein conformational changes (del Rio et al., 2009; Johnson et al., 2007) which occur in focal adhesions (Friedland et al., 2009; Riveline et al., 2001) (Fig.”
Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II–dependent manner (2010, background): “In vitro force-dependent unfolding of talin opens up binding sites for vinculin (del Rio et al., 2009).”
Integrin-mediated mechanotransduction (2016, background): “Forces in the piconewton range lead to the stretching of the talin rod and the exposure (and activation) of the cryptic VBS in the R2R3 domain (del Rio et al., 2009; Yao et al., 2014).”