Expression of microRNA-146 suppresses NF-κB activity with reduction of metastatic potential in breast cancer cells

By D. Bhaumik, G. Scott, S. Schokrpur, C. Patil, J. Campisi, C. Benz. Oncogene, 2008

659 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

MicroRNAs in development and disease. (2011, background): “This miRNA contributes to a negativefeedback effect through direct suppression of the trans- lation of IL-1 receptor associated kinase 1 (IRAK1) and TNF receptor-associated factor 6 (TRAF6).”
miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice (2011, result): “This conclusion is in agreement with previous studies, suggesting that inhibition of miR-146a activity could promote tumor growth and metastasis (Bhaumik et al., 2008; Lin et al., 2008; Hurst et al., 2009; Xia et al., 2009).”
Exosomes from marrow stromal cells expressing miR-146b inhibit glioma growth (2013, background): “Indeed, in addition to EGFR, miR-146 inhibits NF-κB, as well as its upstream regulator TRAF6, and this effect reduces invasion in breast cancer cells [1].”
MicroRNAs — the micro steering wheel of tumour metastases (2009, background): “Further confirming the role of miR-146a in metastasis, the miR-146 family was shown, through repression of IRAK1 (interleukin 1 receptor-associated kinase 1) and TRAF6 (TNF receptor-associated factor 6) expression, to turn off nuclear factor-κB (NF-κB) activity and reduce the metastatic pote”