Present Yourself! By MHC Class I and MHC Class II Molecules

By K. Rock, E. Reits, J. Neefjes. Trends in immunology, 2016

725 citations recorded by the source corpus.

Since the discovery of major histocompatibility complex (MHC) molecules, it took some 40 years to arrive at a coherent picture of how MHC class I and MHC class II molecules really work. This is a story of proteases and MHC-like chaperones that support the MHC class I and II molecules in presenting peptides to the immune system. We now understand that the MHC system shapes both the repertoire of presented peptides and the subsequent T cell responses, with important implications ranging from transplant rejection to tumor immunotherapies. Here we present an illustrated review on the ins and outs of MHC class I and MHC class II antigen presentation.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3088bdad08c7af771cf95dd96de60fcd5abb5839

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In Immunology

1. Chao Yang
2. Monica S. Thakar
3. Alex M. Abel
4. S. Malarkannan

Citations in the corpus

• Natural Killer Cells: Development, Maturation, and Clinical Utilization (2018, background): “Nearly all somatic cells express endogenous peptides on their surface in the context of MHC-I, and this allows the immune system to sample the intracellular environment (201).”