Phagosomes are competent organelles for antigen cross-presentation

By M. Houde, S. Bertholet, É. Gagnon, S. Brunet, Guillaume Goyette, Annie Laplante, Michael F. Princiotta, P. Thibault, D. Sacks, M. Desjardins. Nature, 2003

774 citations recorded by the source corpus.

Subfields: Endocrinology, Immunology

View Paper: https://www.semanticscholar.org/paper/77c32e324d46ac99758bc24fda265ffbb1811407

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. R. Steinman
2. G. Raposo
3. I. Mellman
4. J. Villadangos
5. P. Schnorrer
6. Jacques Banchereau
7. K. Palucka
8. C. Théry

Citations in the corpus

• NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells. (2006, background): “, 1997), the transport of antigen from endosomes and phagosomes into the cytosol (Guermonprez and Amigorena, 2005), and the recruitment of ER proteins to phagosomes (Cresswell, 2005; Guermonprez et al., 2003; Houde et al., 2003).”
• In Vivo Targeting of Antigens to Maturing Dendritic Cells via the DEC-205 Receptor Improves T Cell Vaccination (2004, background): “This receptor may be specialized to target antigens to the exogenous pathway for antigen processing and presentation on MHC class I (20), which likely entails the fusion of elements of the rough endoplasmic reticulum with endocytic vesicles (38, 39).”
• ER–phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells (2003, background): “Mix ER–phagosome compartments bring together all the MHC class I-processin”
• Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo (2007, background): “; the ability to fuse with the endoplasmic reticulum to generate hybrid compartment”
• Matters Arising Quantitative and Dynamic Assessment of the Contribution of the ER to Phagosome Formation (2005, background): “Even a small fractional contribution of the ER to the membrane of the phagosome is compatible with its proposed role in cross-presentation by MHC class I (Ackerman et al., 2003; Guermonprez et al., 2003; Houde et al., 2003).”
• Size-Dependent Immunogenicity: Therapeutic and Protective Properties of Nano-Vaccines against Tumors1 (2004, background): “In this context, it is important to note that DC are particularly efficient at diversion of endosomal/phagosomal (23) Ags for MHC class I presentation (24, 25), and by patocytosis, an uptake mechanism for some hydrophobic nano-particles with the potential to deliver Ags into the cytosol (17, 26).”
• M. tuberculosis and M. leprae translocate from the phagolysosome to the cytosol in myeloid cells. (2007, background): “Several groups have suggested direct fusion between the ER and phagosome during phagocytosis (Houde et al., 2003; Ackerman et al., 2003; Guermonprez et al., 2003), however, quantitative assessment of ER markers on both model latex bead phagosomes and M.”