Extracellular Matrix Reorganization During Wound Healing and Its Impact on Abnormal Scarring

By M. Xue, C. Jackson. Advances in wound care, 2015

1,320 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/74cff6419f4f048c21fcf437c1dab7f32c5e270a

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Citations in the corpus

• Inflammation in Chronic Wounds (2016, background): “These include proteases with broad substrate specificity such as serine proteases, or with narrow specificity such as matrix metalloproteinase (MMP)-2 and -9 that degrade collagen and collagen fragments [31].”
• Collagen in Wound Healing (2021, background): “Even within the keloid scar, there is a heterogeneity to the collagen I/III ratio [14].”
• Wound healing: cellular mechanisms and pathological outcomes (2020, background): “Fibroblasts degrade the provisional matrix by producing MMPs and replace it with a granulation tissue rich in fibronectin, immature collagens and proteoglycans [68].”
• Mechanical induced wounds in fish – a review on models and healing mechanisms (2020, background): “In mammals, the matrix metalloproteinases are secreted by both keratinocytes and macrophages (Schultz et al. 2005), and they degrade extracellular matrixes such as fibrillar collagens, and control inflammation by regulating the activity of cytokines and chemokines (Xue & Jackson 2015).”
• In situ Forming Injectable Hydrogels for Drug Delivery and Wound Repair (2018, unknown): “When damage is extensive and penetrates deep into the dermis or sub-dermal layers as observed in 2nd and 3rd degree burns much of the bulk tissue organization is lost and regenerative cues are either completely absent or deregulated resulting in the production of highly fibrotic scar tissue [19].”
• Treatment Strategies for Infected Wounds (2018, background): “considered as the beginning of angiogenesis and the development of the extracellular matrix [32].”
• Transition from inflammation to proliferation: a critical step during wound healing (2016, background): “lation tissue [5], which fill up the wound gap and provide a scaffold for cell adhesion, migration, growth and differentiation during wound repair [42, 43].”
• Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity (2021, background): “For instance, the switch of collagen fibril architecture from thin and wavy morphology to thick and paralleled arrangement represents tissue fibrosis.(245,246) Generally, hydrogel architecture was decided by the composition itself and the scaffold fabrication approach.”