Solubilizing Excipients in Oral and Injectable Formulations

By R. Strickley. Pharmaceutical Research, 2004

1,364 citations recorded by the source corpus.

Subfields: Molecular Biology, Pediatrics, Perinatology and Child Health, Pharmaceutical Science

View Paper: https://www.semanticscholar.org/paper/74c4d9a1159c23a964d547aeea8d846301ba5f95

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In Molecular Biology

In Pediatrics, Perinatology and Child Health

In Pharmaceutical Science

Citations in the corpus

Nanostructured lipid carriers: Promising drug delivery systems for future clinics. (2016, background): “All the components described below are commercially available in marketed products and/or approved by different regulatory agencies (Generally Recognized As Safe (GRAS), USA FDA IIG).(7,8)”
Polyethylene glycol (PEG): a versatile polymer for pharmaceutical applications (2016, background): “[59] A schematic representation on the role of PEG on absorption of drugs is depicted in Figure 5a.”
Nanoparticle PEGylation for imaging and therapy (2011, background): “Also known as Carboxwax®, it is present in health and beauty aids, including laxatives, toothpastes and eye drops, and is an excipient in tablet formulations [32].”
Cyclodextrins as pharmaceutical solubilizers. (2007, background): “This increases the chemical potential of the drug in solution, increases the apparent saturation solubility and decreases the extent of supersaturation [12,158,152].”
Strategies to Address Low Drug Solubility in Discovery and Development (2013, methodology): “Pain on administration of cosolvent formulations is common and has been largely attributed to hemolysis of red blood cells (Strickley, 2004; Amin and Dannenfelser, 2006).”
An Overview of Micro- and Nanoemulsions as Vehicles for Essential Oils: Formulation, Preparation and Stability (2020, background): “However, non-ionic surfactants represent the first choice because, with respect to ionic ones, they show a safer toxicological profile and are generally accepted even for oral ingestion [54,55].”
Cyclodextrins in drug delivery (2005, background): “Limitations in using organic solvents in injectable formulations include possible drug precipitation, pain, inflammation and haemolysis on injection [109].”