Cyclodextrins as pharmaceutical solubilizers.

By M. Brewster, T. Loftsson. Advanced Drug Delivery Reviews, 2007

1,822 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Pharmaceutical applications of cyclodextrins: basic science and product development (2010, methodology): “Other methods are also applied for determination of the stability constant of drug–CD complexes, such as UV/Vis spectrophotometry and fluorometry, which monitor changes in the drug spectra as a function of the guest–host (i.e. drug– CD) interaction, and NMR, which can be used to determine the value ”
Strategies to Address Low Drug Solubility in Discovery and Development (2013, methodology): “The utility of CDs in assisting the delivery of poorly water-soluble drugs is dictated by the affinity of the drug for the CD as indicated by the magnitude of the drug-CD binding constant.”
Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability (2014, background): “Cyclodextrins are extensively reviewed for their wide applications in the pharmaceutical formulation design including its major use as a solubilizer for poorly soluble drugs [57,59,60].”
Interactions between Polyphenols and Macromolecules: Quantification Methods and Mechanisms (2012, background): “The large and the small rims of the surrounding walls are hydrophilic by virtue of the presence of secondary and primary hydroxyls [ Connors, 1997 ; Brewster & Loftsson, 2007 ].”
In situ Forming Injectable Hydrogels for Drug Delivery and Wound Repair (2018, neutral): “This can both increase the solubility [137] and prolong the availability of un-”