Nanoparticle PEGylation for imaging and therapy

By Jesse V. Jokerst, T. Lobovkina, Richard N. Zare, Sanjiv Sam Gambhir. Nanomedicine, 2011

1,967 citations recorded by the source corpus.

Nanoparticles are an essential component in the emerging field of nanomedical imaging and therapy. When deployed in vivo, these materials are typically protected from the immune system by polyethylene glycol (PEG). A wide variety of strategies to coat and characterize nanoparticles with PEG has established important trends on PEG size, shape, density, loading level, molecular weight, charge and purification. Strategies to incorporate targeting ligands are also prevalent. This article presents a background to investigators new to stealth nanoparticles, and suggests some key considerations needed prior to designing a nanoparticle PEGylation protocol and characterizing the performance features of the product.

Subfields: Biomaterials, Biomedical Engineering, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/aecbf772cfa716fb6dd19d3bedad5341f2ef46be

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomaterials

1. N. Bertrand
2. Xiaoyang Xu
3. J. Hanes
4. O. Farokhzad
5. A. D'Souza
6. Ali Khademhosseini
7. Kruti S. Soni
8. T. Bronich

In Biomedical Engineering

1. N. Bertrand
2. Xiaoyang Xu
3. O. Farokhzad
4. Ali Khademhosseini
5. Kruti S. Soni
6. T. Bronich
7. Xueqing Zhang
8. Faramarz Edalat

In Molecular Biology

1. N. Bertrand
2. Xiaoyang Xu
3. J. Hanes
4. O. Farokhzad
5. L. Ensign
6. A. D'Souza
7. Ali Khademhosseini
8. Kruti S. Soni

Citations in the corpus

• Polyethylene glycol (PEG): a versatile polymer for pharmaceutical applications (2016, background): “Above the cloud point, PEG has lower grafting density and attains mushroom conformation.[11] Mushroom conformation indi-”
• DLS and zeta potential - What they are and what they are not? (2016, background): “[6] J.V. Jokerst, T. Lobovkina, R.N. Zare, S.S. Gambhir, Nanoparticle PEGylation for imaging and therapy, Nanomedicine (London) 6 (2011) 715–728.”
• PEGylation as a strategy for improving nanoparticle-based drug and gene delivery (2015, positive): “This topic has been extensively reviewed previously [11, 12, 43, 44], and here we add additional examples of more recent works.”
• Nanogels: an overview of properties, biomedical applications and obstacles to clinical translation (2015, background): “While PEGylation endows nanosystems with long circulation properties and reduces MPS uptake, eventually opsonization and macrophage clearance still occurs [63].”
• Cancer Nanomedicine: From Targeted Delivery to Combination Therapy (2015, background): “Modification with PEG is currently the gold standard for NP coating [10,20,21].”
• Engineering the Delivery System for CRISPR-based Genome Editing (2018, background): “This protection can be enhanced by modifying the nanoparticles with long-chain PEG molecules [48].”
• Biocompatibility of engineered nanoparticles for drug delivery. (2013, background): “If the density is high the PEG polymers are assumed to be in the brush regime [82].”