The coherent feedforward loop serves as a sign-sensitive delay element in transcription networks.

By S. Mangan, Alon Zaslaver, Uri Alon. 2003

573 citations recorded by the source corpus.

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Citations in the corpus

Network motifs: theory and experimental approaches (2007, background): “The same motifs have since been found in organisms from bacteri”
Efficient sampling algorithm for estimating subgraph concentrations and detecting network motifs (2004, methodology): “FFLs with positive regulations have been shown experimentally to function as a sign-sensitive delay element (Shen-Orr et al., 2002, Mangan et al., 2003).”
Core transcriptional regulatory circuitry in human embryonic stem cells. (2005, background): “When both regulators are positive, the feedforward loop can provide consistent activity that is relatively insensitive to transient changes in input (Mangan et al., 2003; Shen-Orr et al., 2002).”
Centrality Analysis Methods for Biological Networks and Their Application to Gene Regulatory Networks (2008, background): “The best studied motif is the FFL motif which functional properties have been analyzed in detail theoretically and experimentally especially in gene regulatory networks (Mangan and Alon (2003); Mangan et al. (2003); Shen-Orr et al. (2002); Wall et al. (2005)).”
Structure and evolution of transcriptional regulatory networks. (2004, unknown): “However, they have been shown theoretically and experimentally to possess particular kinetic properties that determine the temporal program of expression of the target genes [6 ].”
Aggregation of topological motifs in the Escherichia coli transcriptional regulatory network (2004, background): “However, the emergence of motif clusters and the motif superstructure suggests that the dynamical features of operon activities may be modified compared to that seen in individual motifs [24,25].”
A comprehensive library of fluorescent transcriptional reporters for Escherichia coli (2006, background): “coli , to demonstrate its temporal filtering functio”
Network Motif Discovery Using Subgraph Enumeration and Symmetry-Breaking (2007, background): “The importance of network motifs as information-processing modules has been modeled theoretically [12,21] and verified experimentally [8,13,20,25].”
Signalling ballet in space and time (2010, unknown): “We think that multi-site phosphorylation, and nested feed-forward stabilization loops from ERK and RSK to FOS, result in the observed switch-like expression respons”
Graph theory and networks in Biology. (2006, background): “The work of these papers links motifs to possible biological function and suggests experiments on motifs in real systems such as those described in [153].”
Analysis of Biological Networks (2008, background): “It has been found that in this network type, certain motifs (small recurring patterns, see Chapter 5) such as feed-forward loops or single input modules are overrepresentedwhen comparedwith randomly generated networks [23,36].”