Network motifs: theory and experimental approaches

By Uri Alon. 2007

3,312 citations recorded by the source corpus.

Subfields: Biophysics, Molecular Biology, Computational Biology & Bioinformatics

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Citations in the corpus

An Integrated Micro- and Macroarchitectural Analysis of the Drosophila Brain by Computer-Assisted Serial Section Electron Microscopy (2010, background): “Most of the interconnected pre- and postsynaptic elements of the VNC microvolume engaged in what is called a ‘‘dense overlapping regulon motif’’ [49], defined as a network where a given input element (axon) diverges onto multiple targets, and at the same time, each target element (dendrite) receives”
Encoding and Decoding Cellular Information through Signaling Dynamics (2013, neutral): “have revealed a strong relationship between motif structure, dynamics, and specific function (Alon, 2007; Yosef and Regev, 2011).”
A Directed Protein Interaction Network for Investigating Intracellular Signal Transduction (2011, background): “We examined whether the HPPI2 network with directed PPIs contained network motifs characteristic of biological information-processing networks ( 28 ).”
The Index-Based Subgraph Matching Algorithm (ISMA): Fast Subgraph Enumeration in Large Networks Using Optimized Search Trees (2013, background): “Network motifs act as the fundamental information processing units in cellular regulatory networks [3] and they form the building blocks of larger functional modules (also known as network communities) [4–6].”
Statistical inference of the time-varying structure of gene-regulation networks (2010, background): “This means that closed loops or complex feed-back structures (as in Figure 1A) cannot faithfully be represented, whereas they are known to pervade regulatory networks [17].”
Feedback regulation of EGFR signalling: decision making by early and delayed loops (2011, background): “Second, components of the network are often assembled into recurring units, called network motifs”
Systems biology approaches for advancing the discovery of effective drug combinations (2015, neutral): “bustness [38-40].”
Explainability in Graph Neural Networks: A Taxonomic Survey (2020, background): “neering, graph substructures are highly related to their functionalities [51].”
Human mobility: Models and applications (2017, background): “These 17 trip patterns can be described as motifs; a subnetwork within a complex network [88].”
Vital nodes identification in complex networks (2016, background): “, communities [7] and motifs [8]), and further to uncovering the explicit roles played by such microscopic elements as individual nodes [9] and links [10].”
Defining Network Topologies that Can Achieve Biochemical Adaptation (2009, background): “These transcriptional FFL circuits can perform a variety of functions (Alon, 2007), including pulse generation— a function rather similar to adaptation.”