The Endocrine Regulation of Aging by Insulin-like Signals

By M. Tatar, A. Bartke, Adam Antebi. Science, 2003

1,304 citations recorded by the source corpus.

Subfields: Aging, Cellular and Molecular Neuroscience, Endocrine and Autonomic Systems

View Paper: https://www.semanticscholar.org/paper/74586dd7a48a809fc1ea62b8c130e3351f94e85f

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In Aging

In Cellular and Molecular Neuroscience

In Endocrine and Autonomic Systems

Citations in the corpus

The plasticity of aging: insights from long-lived mutants. (2005, background): “In flies, both juvenile hormone and ecdysone production are decreased in long-lived insulin receptor mutants (Tatar et al., 2003; Tu et al., 2002b), and juvenile-hormone analogs restore the life spans of these animals to normal without affecting wild-type longevity (Tatar et al., 2001).”
A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans (2008, background): “Mutations in components of the insulin/IGF-1 signaling pathway extend lifespan in many organisms [23, 24].”
The evolutionary ecology of senescence (2008, background): “The insulin‐IGF-1 pathway, which is involved in nutritional signalling and metabolic regulation, appears to be of particular importance, and is relatively well conserved across taxa (Gems & Partridge 2001; Tatar, Bartke & Antebi 2003; Nemoto et al. 2004).”
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans (2007, background): “In other organisms, inhibition of insulin / IGF-1 signaling has been linked to reduced rates of protein synthesis (Tatar et al ., 2003; Sharp & Bartke, 2005).”
Early growth conditions, phenotypic development and environmental change (2008, background): “…growth factor-1, growth hormone and thyroid hormone, all of which are interdependent and play an important role in regulating growth and metabolism, in enabling organisms to survive periods of food shortage and in determining lifespan (Gems & Partridge 2001; Tatar et al. 2003; Clemmons 2004).”
A periodic diet that mimics fasting promotes multi-system regeneration, enhanced cognitive performance and healthspan (2015, background): “Dietary composition and calorie level are key factors affecting aging and age-related diseases (Antosh et al., 2011; Blagosklonny et al., 2009; Fontana et al., 2010; Gems and Partridge, 2013; López-Otı́n et al., 2013; Tatar et al., 2003).”
Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates (2012, positive): “Given the links between aging, longevity, and metabolic activity (Lane et al., 1996; Tatar et al., 2003), it is not surprising that several of our model markers are implicated in obesity and metabolism.”
The Cell Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity (2011, positive): “These changes occur coordinately across multiple tissues and organs, in concordance with theories that posit a strong role for the participation of the endocrine system in the regulation of age-related phenotypes (Russell and Kahn, 2007; Tatar et al., 2003).”
Mitochondria-Ros Crosstalk in the Control of Cell Death and Aging (2011, background): “Genes that extend lifespan partially included those involved in oxidative stress response, while partially were clustered in the IGF1/insulin-like signaling pathway [152, 153].”