N-Acetylcysteine--a safe antidote for cysteine/glutathione deficiency.

By K. Atkuri, John J. Mantovani, L. A. Herzenberg, Leonore Herzenberg. Current opinion in pharmacology (Print), 2007

730 citations recorded by the source corpus.

Subfields: Biochemistry, Pharmacology, Rheumatology

View Paper: https://www.semanticscholar.org/paper/35e44dd346d93012663a8866b17d9a35ff50d726

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. A. Holmgren
2. Barry Halliwell
3. M. Murphy
4. C. Winterbourn

In Pharmacology

1. Linda Partridge
2. Barry Halliwell
3. C. Winterbourn

Citations in the corpus

• Circulating microRNAs, potential biomarkers for drug-induced liver injury (2009, background): “N-acetylcysteine (NAC) is an amino acid derivative that can be quickly converted into intracellular GSH in the body (10).”
• Clinical Relevance of Biomarkers of Oxidative Stress (2015, background): “In particular, studies on GSH in acquired immunodeficiency syndrome (AIDS) and other conditions have shown very clearly that rather than in plasma, GSH should be measured within cells by fluorescence activated cell sorting (72).”
• Antioxidant Role for Lipid Droplets in a Stem Cell Niche of Drosophila (2015, positive): “The antioxidant N-acetyl cysteine (NAC) is a ROS scavenger and it replenishes the reduced glutathione pool (Atkuri et al., 2007).”
• Glutathione dysregulation and the etiology and progression of human diseases (2009, background): “Inhaled N-acetylcysteine is thought to increase clearance of sputum in the airways by reducing disulfide bonds and lowering mucus viscosity , but does not increase systemic GSH levels (Atkuri et al., 2007).”
• Unravelling the Biological Roles of Reactive Oxygen Species (2011, background): “A further point is the widespread use of N-acetylcysteine (NAC) as a generic antioxidant in biological situations (Atkuri et al., 2007).”
• The chemistry and biological activities of N-acetylcysteine. (2013, background): “NAC has relatively low toxicity and is associated with mild side effects such as nausea, vomiting, rhinorreah, pruritus and tachycardia [4].”