CpG island methylator phenotype in cancer

By Jean-Pierre Issa. Nature Reviews. Cancer, 2004

1,085 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/33c89eea355059b5433a61fb291981011bf32fb8

How researchers see this paper

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In Genetics

1. Peter W. Laird
2. Melanie Ehrlich
3. Christoph Bock
4. M. Smulders
5. G. Klerk

In Molecular Biology

1. Peter W. Laird
2. Melanie Ehrlich
3. Edward L. Giovannucci
4. Manel Esteller
5. Christoph Bock
6. Partha M. Das
7. R. Singal
8. S. Baylin

Citations in the corpus

• Cancer epigenetics. (2005, background): “One controversial putative epigenetic control defect is the CpG island methylator phenotype (CIMP) first reported in colorectal cancer (151), but since described for several other types of cancer as well (152).”
• CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer (2008, background): “[1,2] A number of tumor suppressor genes are silenced by promoter CpG island methylation in colon cancers.”
• DNA hypomethylation in cancer cells (2009, background): “13 Issa JP: CpG island methylator phenotype in cancer. Nat. Rev. Cancer 4, 988–993 (2004).”