Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA

By Takeshi Saito, D. Owen, F. Jiang, J. Marcotrigiano, M. Gale. Nature, 2008

787 citations recorded by the source corpus.

Subfields: Epidemiology, Hepatology, Immunology

View Paper: https://www.semanticscholar.org/paper/15cb7ce0a9b033208be6ecfc0e149dbf1f8f0947

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Shizuo Akira
2. O. Takeuchi
3. C. Reis e Sousa
4. A. García‐Sastre
5. M. Gale
6. R. Medzhitov
7. Taro Kawai

In Hepatology

1. Shizuo Akira
2. O. Takeuchi
3. M. Gale

In Immunology

1. Shizuo Akira
2. O. Takeuchi
3. Anna Marie Pyle
4. M. Gale
5. Taro Kawai
6. Mitsutoshi Yoneyama
7. T. Fujita
8. A. Bowie

Citations in the corpus

• Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing (2010, background): “Additionally, 5′ppp containing RNAs rich in U residues have been found to act as more potent inducers of RIG-I, indicating that sequence composition might play a role in activation (22).”
• Structural Basis of RNA Recognition and Activation by Innate Immune Receptor RIG-I (2011, methodology): “The observed fluorescence anisotropy (robs) as a function of protein concentration (Pt) was fit to equations (1) and (2) to obtain the equilibrium dissociation constant, Kd.”
• RNA recognition and signal transduction by RIG‐I‐like receptors (2009, background): “It should be noted that a recent report suggested that RIG-I requires a polyuridine motif at the 3¢-non-translated region of the HCV genome; however, it remains to be addressed whether this is the case for other viruses (63).”
• 5′-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I (2009, background): “Recently, it was suggested that viral RNA requires A- or U-rich stretches to activate RIG-I (15).”
• Viral evasion and subversion of pattern-recognition receptor signalling (2008, background): “Although the 5′ triphosphate is necessary, it is not sufficient for RIG-I activatio”
• RIG-I detects viral genomic RNA during negative-strand RNA virus infection. (2010, background): “, 2008) and, in some cases, to require specific structural determinants or sequence motifs (Marques et al., 2006; Saito et al., 2008; Schlee et al., 2009b; Schmidt et al., 2009; Uzri and Gehrke, 2009).”
• Pattern recognition receptors and inflammation. (2010, methodology): “Poly(U)- or poly(A)-rich sequences from the HCV RNA 30 untranslated region (UTR) are responsible for RIG-I-mediated IFN production, based on RNAs generated by in vitro transcription using T7 polymerase (Saito et al., 2008).”