Identification of a cancer stem cell in human brain tumors.

By Sheila K. Singh, I. Clarke, Mizuhiko Terasaki, Victoria E Bonn, C. Hawkins, J. Squire, P. Dirks. Cancer Research, 2003

5,164 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/73a8837400b13f64796e41e12adc6621b10a4f39

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Citations in the corpus

• Human Melanoma Initiating Cells Express Neural Crest Nerve Growth Factor Receptor CD271 (2010, unknown): “Identifications of cancer stem cells (CSCs) in solid tumors3, 5-9 provided evidence that CSC appear to recapitulate the developmental program of corresponding normal tissue stem or progenitor cells, although in an incomplete and disorganized manner10.”
• Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation (2012, methodology): “Since then, several methods have been used to generate tumor spheroids: spontaneous aggregation [19,20], spinner flasks [21], rotary cell culture systems [3,22], poly-2-hydroxyethyl methacrylate (polyHema)-coated plates [23,24], hanging drops [25], liquid overlay on agar [26-28], low binding plates ”
• Tissue repair and stem cell renewal in carcinogenesis (2004, background): “In addition, cells with some of the properties of neural stem cells (NSCs), such as the ability to produce differentiated neurons and glia in vitro and in vivo and enhanced renewal activity, have recently been isolated from brain tumours and brain-tumour-derived cell line”
• Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy (2008, background): “The ability to both self-renew and differentiate into heterogeneous cell types is the definition of a stem cell that is thought to be functionally mimicked by cancer stem cells [7,22-25].”
• Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors. (2006, background): “Nevertheless, nestin was one of the first markers of neural stem cells to be identified (46) and its expression has been shown in a subset of cells within neurospheres derived from primary human medulloblastoma, suggesting it marks stem-like cells in these tumors (32, 33).”
• An integrated computational/experimental model of tumor invasion. (2006, background): “ation, such as stem cells, as was recently suggested (54).”
• Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. (2006, background): “However, recent evidence in human and animal studies suggests neural stem cells as an alternate cellular origin of gliomas (Caussinus and Gonzalez, 2005; Singh et al., 2003; Zhu et al., 2005).”