Channelrhodopsin-1: A Light-Gated Proton Channel in Green Algae

By G. Nagel, D. Ollig, M. Fuhrmann, S. Kateriya, A. Musti, E. Bamberg, P. Hegemann. Science, 2002

1,109 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/738e6e76e85dfe6b68e2a0515129399b6204f12a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomedical Engineering

1. Karl Deisseroth
2. Antonio Rangel
3. John A. Clithero

In Cellular and Molecular Neuroscience

1. Karl Deisseroth
2. Ed Boyden
3. Lief Ericsson Fenno
4. Ofer Yizhar
5. Feng Zhang
6. Liping Wang
7. A. Aravanis
8. Mark T. Harnett

In Cognitive Neuroscience

1. Karl Deisseroth
2. Ed Boyden
3. Feng Zhang
4. Lief Ericsson Fenno
5. Ofer Yizhar
6. Liping Wang
7. György Buzsáki
8. Y. Dudai

Citations in the corpus

• An optical neural interface: in vivo control of rodent motor cortex with integrated fiberoptic and optogenetic technology (2007, background): “Leveraging advances in chemical biology and molecular genetics, several groups have developed novel optical techniques to control neural activity, involving optical uncaging of chemically modified neurotransmitters [25–27], chemical modification of native proteins to render them light-responsive [28”
• Light activation of channelrhodopsin-2 in excitable cells of Caenorhabditis elegans triggers rapid behavioral responses. (2005, background): “Channelrhodopsins [3, 4] are 7-transmembrane-helix proteins that resemble the light-driven proton pump bacteriorhodopsin [5], and they also utilize the chromophore all-trans retinal, but to open an intrinsic cation pore.”
• Channelrhodopsin-2 and optical control of excitable cells (2006, background): “and introduction of light-sensitive proteins into otherwise light-insensitive cell”
• Characterization of engineered channelrhodopsin variants with improved properties and kinetics. (2009, background): “Significant photocurrent is detected through ChR1 only when extracellular pH is lowered, which led to the previous conclusion that ChR1 is more selective for protons than other cations ( 1 ).”
• The Development and Application of Optogenetics (2011, background): “…Paz, F. Schneider, S. Tsunoda, R. Fudim, C. Ramakrishnan, J. Huguenard, P. Hegemann & K. Deisseroth, submitted), composed of the first two and one-half helices of ChR1 (a poorly expressing relative of ChR2 from the same organism) (Nagel et al. 2002) and the last four and one-half helices of VChR1.”