Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia

By C. Mullighan, S. Goorha, I. Radtke, C. Miller, E. Coustan-Smith, J. Dalton, Kevin Girtman, S. Mathew, Jing Ma, S. Pounds and 6 more. Nature, 2007

1,888 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/dc9c7bb95c50e87438b85f65332a0ba0e451ca81

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Citations in the corpus

JAK mutations in high-risk childhood acute lymphoblastic leukemia (2009, methodology): “GSEA (28) was performed as described previously (2, 4) by using the collection of publicly available gene sets (www.”
Absolute quantification of somatic DNA alterations in human cancer (2012, background): “In principle, one could infer absolute copy-numbers by rescaling relative data based on cytological measurements of DNA mass per cancer cell 16, 17, 18 , or by single-cell sequencing approaches 15 .”
Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1. (2008, neutral): “Collectively, these data fit with multistep oncogenesis of T-ALL (33, 34), in which oncogenes were first activated by vector insertional mutagenesis, followed by accumulation of secondary genome rearrangements, including point mutations as well as gene deletions and amplifications.”
Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia (2012, background): “Deletions, translocations, and sequence mutations of PAX5 are detected in approximately 30% of B-ALL patients (Mullighan et al., 2007), and this inversion represents another mechanism for PAX5 inactivation.”
The landscape of somatic copy-number alteration across human cancers (2010, neutral): “EGFR (1) FGFR1 (3) IKBKB (6) MYC (1) CCND1 (3) KRAS (2) CDK4 (7) HMGA2 (1) MDM2 (1) CCT2 (2) NKX2-1 (3) IGF1R (4) ERBB2 (6) CCNE1 (1) CRKL (11) IRAK1 (53) ×10–100 ×10–100 ×10–80 ×10–80 ×10–60 ×10–60 ×10–40 ×10–40 ×10–20 ×10–20 1.”
Activation of proto-oncogenes by disruption of chromosome neighborhoods (2015, methodology): “The deletion on the bottom indicates the minimally deleted region identified in (26).”
Identification of RPS14 as a 5q- syndrome gene by RNA interference screen (2008, positive): “The recent discovery of monoallelic deletions or mutations in PAX5 in acute lymphoblastic leukaemia supports this hypothesis 22 .”
Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation (2011, methodology): “The predominance of point mutations over CNAs is notable, as it is unusual com pared with most cancer types (Mullighan et al., 2007; Lenz et al., 2008; Parsons et al., 2011).”