Leukaemia stem cells and the evolution of cancer-stem-cell research

By B. Huntly, D. Gilliland. Nature Reviews. Cancer, 2005

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Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. (2006, background): “However, the true relatedness of previously reported TSCs to normal stem cells and their exact relevance to our current in vitro and in vivo models of cancer, as well as to primary human tumors in situ, remain unclear (Dontu et al., 2003; Huntly and Gilliland, 2005; Kim et al., 2005; Pardal et al., ”
The biology of cancer stem cells. (2007, background): “In a mouse model, Hoxb3, Hoxb8, and Hoxa10 are associated with leukemogenesis (Huntly & Gilliland 2005).”
Radial glia cells are candidate stem cells of ependymoma. (2005, background): “Notably, the NOTCH cell signal pathway and HOX family of transcription factors, which we identified as upregulated in supratentorial and spinal ependymomas, respectively, regulate stem cell self-renewal (Huntly and Gilliland, 2005; Pardal et al., 2003).”
Targeting cancer stem cell pathways for cancer therapy (2020, background): “CSCs isolated from original tumor tissue that were transplanted into severe combined immunodeficiency disease (SCID) mice then formed new tumors.(15) CSCs and normal stem cells also share some of the same regulatory signaling pathways, such as the Wnt/β-catenin,(16) Sonic Hedgehog (Hh),(17) and Notc”