Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor.

By Da-Zhi Wang, Priscilla S. Chang, Zhigao Wang, L. Sutherland, J. Richardson, E. Small, P. Krieg, E. Olson. Cell, 2001

941 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/72ad0decb77682c49f75ea3d5fa2b273666ccd31

How researchers see this paper

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In Molecular Biology

1. E. Olson
2. J. Richardson
3. R. Bassel-Duby
4. E. Small
5. X. Qi
6. L. Sutherland
7. Thomas Braun
8. Christopher S. Chen

Citations in the corpus

• Mechanical control of stem cell differentiation (2008, background): “SRF and its co-factors regulate the expression of smooth muscle proteins, principally structural and contractile proteins associated with the actin cytoskeleton (Cen et al., 2003; Selvaraj and Prywes, 2003; Wang et al., 2001).”
• Serum response factor: toggling between disparate programs of gene expression. (2003, background): “2 95 ccaatttttg (+6714) [87,88] NOV e CCN3 4 8q24.”
• Actin dynamics control SRF activity by regulation of its coactivator MAL. (2003, methodology): “Expression in basic residues: B1, a basic region homologous to oneof actin mutants S14C and V159N, which apparently first identified in myocardin (Wang et al., 2001), and B2,stabilize F actin and strongly activate SRF (Posern et a related sequence between RPEL motifs 2 and 3 (seeal., 2002) also…”
• Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster. (2009, background): “, myocardin, which plays a pivotal role as a coregulator of SRF in SMCs but is also expressed in adult cardiomyocytes (27).”
• The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation (2006, methodology): “Northern blot analysis to detect primary transcripts of miRNAs was done as describe”
• MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury. (2009, background): “The cardiovascular coactivator myocardin interacts with SRF and stimulates smooth muscle differentiation ( Wang et al. 2001, 2003; Chen et al. 2002; Du et al. 2003; Yoshida et al. 2003).”