The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation

By Jian-Fu Chen, Elizabeth M. Mandel, J. Thomson, Qiulian Wu, T. Callis, Scott M. Hammond, F. Conlon, Da-Zhi Wang. Nature Genetics, 2006

2,783 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/37ce1e137738c7c879599b56c72bbbcfdb66ff2e

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Citations in the corpus

MicroRNAs: key regulators of stem cells (2009, background): “pl?acc=MI0000450">miR-133 are co-transcribed and processed specifically in adult cardiac and skeletal muscle tissues, but promote myogenesis in distinct fashion”
MEF2: a central regulator of diverse developmental programs (2007, background): “Interestingly, miR-1 has been shown to target class II HDACs (such as HDAC4) (Chen et al., 2006) to establish a positive feed-forward mechanism for MEF2 activation and skeletal muscle differentiation (Fig.”
MicroRNAs in development and disease. (2011, background): “While both miR-1 and miR-133 simultaneously increase during differentiation of C2C12, they were reported to have antagonistic effects (91).”
Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans. (2010, result): “As expected, miR-499 and miR-208a were detected only in heart, whereas miR-1 and miR-133a were highly expressed both in skeletal muscle and heart (see Supplementary material online, Figure S1), which is in agreement with previous reports.(11,19,20) Then, realtime PCR analysis, a more sensitive metho”
MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis (2009, methodology): “Wild-type or mutated 3′ UTR sequences of Ets1 or Smo (encoding smoothened) were cloned into the modified pGL3-control vector (Promega) as describe”
miRTarBase update 2022: an informative resource for experimentally validated miRNA–target interactions (2021, background): “miRNAs play a role in crucial cell activities such as cellular signaling, metabolism, cell differentiation and proliferation, and apoptosis by controlling the expression of multiple genes and are abundant in cells (6,7).”
Making or breaking the heart: from lineage determination to morphogenesis. (2006, background): “As in cardiac muscle, miR-1 promotes the differentiation of skeletal myoblasts in culture, but interestingly, miR-133a inhibits differentiation and promotes proliferation of myoblasts (Chen et al., 2006).”
MicroRNAs in cancer: small molecules with a huge impact. (2009, background): “Interestingly, introduction of miR-29s into lung cancers and AMLs results in reactivation of silenced tumor suppressors and inhibition of tumorigenesis.40,42 Loss of miR-290 cluster in Dicer-deficient mouse embryonic stem cells leads to the downregulation of DNMT3a, DNMT3b, and DNMT1 through upmodul”
microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart. (2008, background): “SRF, a direct target for regulation by miR-133 (Chen et al. 2006), was up-regulated in dKO hearts, as were numerous smooth muscle structural genes that are regulated by SRF.”
Therapeutics Data Commons: Machine Learning Datasets and Tasks for Drug Discovery and Development (2021, background): “MicroRNA (miRNA) is small noncoding RNA that plays an important role in regulating biological processes such as cell proliferation, cell differentiation and so on (Chen et al. 2006).”
Satellite cells and the muscle stem cell niche. (2013, background): “These myogenic microRNAs, in conjunction with other microRNAs, modulate the expression levels of key myogenic transcription factors and regulators, such as Pax3 (119, 196, 231), Pax7 (94, 139), SRF (93), c-Met (526, 577), and Dek (98) during satellite cell activation/proliferation and differentiatio”
MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death (2008, background): “In addition, an expression analysis of 217 Oncogene Table 1 miRNAs with relevance in cancer and cell death miRNA Normal function Cancer relevance Cell death relevance Targets References Let-7/miR-98 Upregulated late during Caenorhabditis elegans development; increased expression in differentiated ce”
Role of microRNAs in vascular diseases, inflammation, and angiogenesis. (2008, background): “There is an increasing evidence that specific miRNAs are involved in various biological processes such as cardiogenesis, skeletal muscle proliferation and differentiation, brain morphogenesis, oncogenesis, and haematopoietic lineage differentiation.(12,13,25,32,33) While the function of Dicer and Dr”
The Role of MicroRNAs in Human Diseases (2010, background): “Studies have shown that three mirRNAs (miR-1, miR-133, and miR-208) are highly expressed in the heart (23, 75) and are important regulators of heart development and myocyte differentiation (72, 76 - 78 ) .”