Microtubules as a target for anticancer drugs

By M. Jordan, Leslie Wilson. Nature Reviews. Cancer, 2004

4,395 citations recorded by the source corpus.

Subfields: Cancer Research, Cell Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/7287b91aa0ef897cc89a965c9f02cee230c0a785

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Citations in the corpus

p21-activated kinases in cancer (2006, background): “This aspect of tumour biology has been exploited extensively in the development of cancer therapie”
RefFinder: a web-based tool for comprehensively analyzing and identifying reference genes (2023, background): “However, recent studies have demonstrated that the transcription levels of housekeeping genes also vary in different cell types and developmental stages as well as being affected by different experimental conditions including varying treatments (Ahn et al. 2008; Jordan and Wilson 2004; Yu et al. 202”
Molecular mechanisms of drug resistance (2005, background): “Microtubules are highly dynamic cytoskeletal fibres composed of tubulin subunits (most commonly αand β-tubulin) that have crucial roles in maintaining cell shape, in cell signalling, in cell division and mitosis, and in the transport of vesicles and mitochondria and other cellular components through”
How Taxol/paclitaxel kills cancer cells (2014, background): “Phenotypically, paclitaxel treatment arrests a diverse array of cell types in mitosis, in both animal tumor models and cell culture (Fuchs and Johnson, 1978; Schiff and Horwitz, 1980; Milas et al., 1995; Jordan and Wilson, 2004; Orth et al., 2008).”
Natural compounds for cancer treatment and prevention. (2009, background): “Drugs that interfere with microtubule function lead to failure of alignment of the daughter chromosomes and their bipolar attachment to the mitotic spindle; this effect leads to mitotic arrest at the metaphase/anaphase transition, followed by apoptosis [22].”
Recent advances in the development of protein–protein interactions modulators: mechanisms and clinical trials (2020, background): “Such effect further destroys the rapidly differentiated tumor cells during mitosis, stagnates the cell cycle, and in turn induces the tumor cells to undergo apoptosis.(236) Paclitaxel (Fig.”
Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats (2014, methodology): “To investigate whether transport of aggregated α-synuclein was microtubule dependent, we treated the cultures with 10 nM vinblastine, an agent known to destabilize microtubules [2, 20], for 1 h before the FRAP experiment.”
Microtubule-binding agents: a dynamic field of cancer therapeutics (2010, background): “It is now clear that alterations in microtubule dynamics are the main mechanism of action of microtubule-binding agent”
Mitotic catastrophe: a mechanism for avoiding genomic instability (2011, background): “Moreover, an entire class of anticancer agents (that is, microtubular poisons, whether they are hyperpolymerisers, such as taxanes and epothilones, or depolymerising agents, such as vinca alkaloids) trigger mitotic catastrophe by binding to tubulin and disrupting the mitotic spindl”
Cell mechanics and the cytoskeleton (2010, neutral): “The ability of the mitotic spindle to find and align chromosomes depends, in part, on the complex assembly dynamics of individual microtubule”
Cell cycle kinases as therapeutic targets for cancer (2009, background): “When this happens, the mitotic checkpoint is activated, thereby inducing a prolonged mitosis which ends with cell deat”
Shared and separate functions of polo-like kinases and aurora kinases in cancer (2010, background): “Well-known examples of these drugs are those that perturb the formation of the mitotic spindle such as taxanes and vinca alkaloids”
Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs. (2008, background): “Microtubule toxins are used extensively during chemotherapy, demonstrating impressive efficacy in the treatment of breast and ovarian cancer (Jordan and Wilson, 2004).”
Stochastic mechano-chemical kinetics of molecular motors: A multidisciplinary enterprise from a physicist’s perspective (2012, background): “These molecules are potential anti-cancer drugs because of the corresponding implications of the dynamic instability in cell division [2266, 2267, 2268].”
On the road to cancer: aneuploidy and the mitotic checkpoint (2005, background): “Drug-mediated mitotic-checkpoint-dependent arrest is often followed by cell deat”
The function of terpene natural products in the natural world. (2007, background): “Similarly, the blockbuster anticancer diterpene paclitaxel (Taxol), isolated from yew, kills tumor cells by binding to tubulin, which interferes with microtubule dynamics and arrests mitosi”