Type Iγ phosphatidylinositol phosphate kinase targets and regulates focal adhesions

By K. Ling, Renee L. Doughman, Ari J. Firestone, M. Bunce, R. Anderson. Nature, 2002

422 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/727306c5bd22fbe4120d6bcc918bdcb366f0258f

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Citations in the corpus

Adhesion-dependent cell mechanosensitivity. (2003, background): “It was recently shown that type I-γ isoform of phosphatidylinositol phosphate kinase, an enzyme that generates phosphatidylinositol-4,5-bisphosphate (PIP2), is concentrated in the focal adhesion, bound to talin (Di Paolo et al. 2002, Ling et al. 2002).”
Focal adhesion kinase: in command and control of cell motility (2005, background): “PIPKIγ is phosphorylated by a FAK–Src complex, which facilitates increased PIPKIγ activity (and, therefore, increased production of PtdIns(4,5)P 2 ) and increased PIPKIγ association with tali”
Activation of a vinculin‐binding site in the talin rod involves rearrangement of a five‐helix bundle (2004, background): “PIP2 has been implicated in the allosteric activation of the integrin-binding site(s) in talin (Martel et al, 2001) and also in the activation of vinculin (Gilmore and Burridge, 1996).”
Genetic and cell biological analysis of integrin outside-in signaling. (2009, background): “The lipid kinase phosphatidylinositol 4-phosphate 5-kinase type I g (PIPKIg) localizes to FAs via an interaction with talin (Di Paolo et al. 2002; Ling et al. 2002), and may generate a local elevation in PtdIns-4,5-P2 concentration at adhesion sites.”
Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions (2010, background): “One potential mechanism regulating adhesion assembly is regulation of phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] generation at sites of adhesion (Ling et al., 2002), which in turn could regulate talin-dependent activation of integrin-ligand binding (Nayal et al., 2004).”
Calpain-mediated proteolysis of talin regulates adhesion dynamics (2004, neutral): “and local phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P 2 ) generatio”