Aging Gracefully: Compensatory Brain Activity in High-Performing Older Adults

By Roberto Cabeza, Nicole D. Anderson, Jill K. Locantore, Anthony Randal McIntosh. NeuroImage, 2002

1,995 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/724f6b2b427d39239a1203a5d494ee0c5a13028b

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In Cognitive Neuroscience

Citations in the corpus

Age-related Changes in Brain Activity across the Adult Lifespan (2006, background): “On the other hand, the opposite result, more prefrontal activity during memory tasks in older adults than in younger adults, also has been reported (Gutchess et al., 2005; Morcom, Good, Frackowiak, & Rugg, 2003; Cabeza, Anderson, Locantore, & McIntosh, 2002; Grady, Bernstein, Siegenthaler, & Beig,”
Harnessing neuroplasticity for clinical applications (2011, positive): “Such adaptive plasticity might play a useful role in compensation for ageing effects (Cabeza et al., 2002; Park and Reuter-Lorenz, 2009) and may also be amenable to facilitatory interventions involving drugs (Floel et al., 2008) or non-invasive brain stimulation (Hummel et al., 2010).”
Aging, training, and the brain: A review and future directions (2009, positive): “The results of Cabeza et al. (2002) provide an instructive example: Older adults whose performance matched young adults' on a memory task had more bilateral patterns of activation in prefrontal cortex than did young adults.”
Frontal circuitry degradation marks healthy adult aging: Evidence from diffusion tensor imaging (2005, background): “Finally, functional imaging studies of normal aging provide converging evidence for the recruitment by older individuals of wider-spread brain systems especially when performing frontallybased tasks to achieve performance levels of younger adults (Cabeza et al., 2002).”
Que PASA? The posterior-anterior shift in aging. (2008, background): “Regions are consistent with previous studies assessing task-independent (Cabeza et al. 2002) and default activity (Lustig et al.”
Growing together and growing apart: Regional and sex differences in the lifespan developmental trajectories of functional homotopy (2010, background): “Based on evidence of decreasing lateralization in normal aging (Cabeza et al., 2002; Buckner, 2004; Li et al., 2009; Park and Reuter-Lorenz, 2009), we also predicted quadratic or cubic age-related changes in homotopic RSFC.”
Brain reserve and dementia: a systematic review (2005, background): “Capacity for functional reorganization is also emerging as a powerful compensatory mechanism in late life, with atypical brain networks active in mediating mnemonic performance in successful ageing and early AD (Stern et al. 2000; Cabeza et al. 2002; Grady et al. 2003).”
Cognitive Reserve and Alzheimer Disease (2006, result): “For example, in several studies, some elders showed additional activation in areas contralateral to those activated by younger subjects; the elders who showed this additional activation performed better than those who did not, indicating that it was compensatory.(66,67) Similarly, studies have shown”
Cognitive Neuroscience of Aging (2008, background): “Because this pattern of overrecruitment in older adults has been reported in those who perform better on the task (Cabeza et al. 2002; Grady et al. 2005), there have been suggestions that additional recruitment of brain activity compensates for age-related changes in brain structure and function.”