Cognitive Reserve and Alzheimer Disease

By Yaakov Stern. Alzheimer Disease and Associated Disorders, 2006

733 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Physiology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/5b032763dd33290793fbc1542564e3e9ca00b588

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cognitive Neuroscience

In Physiology

In Psychiatry and Mental health

Citations in the corpus

Examining the motivation-performance relationship in competitive sport: a cluster-analytic approach. (2012, background): “Concurrent with the cognitive reserve theory, participation in cognitive simulating leisure activities can accumulate cognitive reserve, which may in turn maintain or improve cognitive functioning (Stern, 2006; Verghese, Cuiling, Katz, Sanders, & Lipton, 2009).”
2016 Alzheimer's disease facts and figures (2016, unknown): “Some researchers believe that having more years of education builds a “cognitive reserve” that enables individuals to better compensate for changes in the brain that could result in symptoms of Alzheimer’s or another dementia [76,78,79].”
Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain (2019, background): “Researchers have found a relationship between frequent social activity and improved cognitive function (Stern, 2006).”
Education and Dementia in the Context of the Cognitive Reserve Hypothesis: A Systematic Review with Meta-Analyses and Qualitative Analyses (2012, background): “Mortality (N = 8) Stern et al. [a113] 1995 USA Cohort 246 Patients with more education had increased mortality.”
Network Analysis of Intrinsic Functional Brain Connectivity in Alzheimer's Disease (2008, background): “An intriguing (and testable) hypothesis is that the ability to make such compensatory changes in frontal lobe connectivity may account in part for the ‘‘cognitive reserve’’ phenomenon [31] that allows some patients to perform better than others despite equivalent pathological burdens.”
Calcium and neurodegeneration (2007, background): “In addition, cognitively challenging lifestyles may protect neurons against AD (Stern, 2006).”
Hypothetical model of dynamic biomarkers of the Alzheimer’s pathological cascade (2010, unknown): “97 Similarly, as yet undiscovered neuroprotective genes might shift the cognitive decline curve to the right, away from the amyloid curve, whereas genes that amplify the effect of A β dysmetabolism on the neurodegenerative cascade might shift the cognitive decline curve closer to the amyloid curve.”
Education and Cognitive Functioning Across the Life Span (2020, background): “All these scenarios have been empirically observed (see, e.g., Stern, 2006, 2009, 2012, for reviews) and can be explained without evoking the concept of cognitive reserve.”
Learning brain connectivity of Alzheimer’s disease by sparse inverse covariance estimation (2010, methodology): “This is consistent with previous literature and has been interpreted as compensatory reallocation or recruitment of cognitive resources (Gould et al., 2006; Stern, 2006; Becker et al., 1996; Woodard et al., 1998; Saykin et al., 2004; Grady et al., 2003).”
What is normal in normal aging? Effects of Aging, Amyloid and Alzheimer’s Disease on the Cerebral Cortex and the Hippocampus (2014, background): “Education is an often-used proxy for cognitive reserve, which is defined as the ability to maintain cognitive function despite high levels of AD pathology (Stern et al., 1999; Stern, 2006, 2012).”
Global Epidemiology of Dementia: Alzheimer's and Vascular Types (2014, background): “These results do not necessarily argue against the education-related “cognitive reserve” hypothesis in dementia [56] but may imply that other environmental factors, such as diet and physical activity, might be even more important risk factors for dementia than low educational background.”