The Relationship between Aβ and Memory in the Tg2576 Mouse Model of Alzheimer's Disease

By M. Westerman, Deirdre Cooper-Blacketer, A. Mariash, L. Kotilinek, T. Kawarabayashi, L. Younkin, G. Carlson, S. Younkin, K. Ashe. Journal of Neuroscience, 2002

653 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Computational Theory and Mathematics, Physiology

View Paper: https://www.semanticscholar.org/paper/71f3934e2f683cefe2814e025928bfd939ca3ec6

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Citations in the corpus

APP processing and synaptic function. (2003, neutral): “…amyloid-dependent physiological and behavioral deficits in transgenic mice can occur in the absence of cellIt is of interest, and potential clinical relevance, that inhibiting excitatory synaptic transmission or blocking death (Hsiao et al., 1996; Morgan et al., 2000; Westerman et al., 2002).”
Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model. (2004, positive): “Besides training mice, the visible testing phase was used to exclude mice that have visual or motor deficits (Westerman et al., 2002).”
Natural oligomers of the amyloid-β protein specifically disrupt cognitive function (2005, background): “β-amyloid(1-40) effects on behavior and memory.”
Inflammatory processes in Alzheimer's disease. (2007, background): “, 2000) and improved performance in behavioral tasks (Lim et al., 2001; Westerman et al., 2002).”
Neurovascular regulation in the normal brain and in Alzheimer's disease (2004, background): “Transgenic mice overexpressing the SWEDISH MUTATION of App develop cognitive impairment at 6 months of age and amyloid plaques at 9–12 month”
Age-Dependent Neurofibrillary Tangle Formation, Neuron Loss, and Memory Impairment in a Mouse Model of Human Tauopathy (P301L) (2005, methodology): “Age-dependent development of cognitive impairments The effect of tauP301L expression on spatial reference memory in rTg(tauP301L)4510 mice was examined using the Morris water maze (Westerman et al., 2002).”
Aβ Oligomers – a decade of discovery (2007, background): “…1995), memory impairment and changes in neuron form and function observed in APP transgenic mice can occur well before the first signs of amyloid deposition (Moechars et al. 1999, Hsia et al. 1999, Chapman et al. 1999, Mucke et al. 2000, Westerman et al. 2002, Dineley et al. 2002, Wu et al. 2004).”
Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models (2014, background): “These spatial working memory deﬁcits are generally accepted to be present across the rest of the life span for this model (Hsiao et al., 1996; Westerman et al., 2002; Arendash et al., 2004).”
Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration (2010, methodology): “Examination of spatial reference memory with the Morris water maze (Westerman et al., 2002) demonstrated cognitive impairments in 4.5, but not 1.3, month-old rTgP301L mice (*p < 0.05 by repeated- measures ANOVA; Figures 1A–1C).”