Dynamic Proteomics of Individual Cancer Cells in Response to a Drug

By A. Cohen, N. Geva-Zatorsky, Eran Eden, M. Frenkel-Morgenstern, Irina Issaeva, Alex Sigal, Ron Milo, Cellina Cohen-Saidon, Yuvalal Liron, Zvi Kam and 4 more. Science, 2008

622 citations recorded by the source corpus.

Subfields: Biophysics, Spectroscopy

View Paper: https://www.semanticscholar.org/paper/71f175342f227ce4b13a9e158b2724b2e11bd90e

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Citations in the corpus

Encoding and Decoding Cellular Information through Signaling Dynamics (2013, positive): “Single-cell imaging reveals that cleavage is rapid but with a variable delay from cell to cell. and additional studies is that individual cells differ widely in their dynamical responses even when challenged with the same stimulus (Cohen et al., 2008; Lee et al., 2009).”
Structure and dynamics of molecular networks: A novel paradigm of drug discovery: A comprehensive review (2012, methodology): “Following a treatment with a chemotherapeutic agent almost all of 1000 tagged proteins of cancer cells showed a dynamic response, when their temporal expression levels and localization were tracked (Cohen et al., 2008).”
Cellular heterogeneity: when do differences make a difference? (2010, background): “…clonal populations under carefully controlled laboratory conditions, the dynamics and responses of single cancer cells to drugs can vary widely (Cohen et al., 2008; Gascoigne and Taylor, 2008), and drug-tolerant states can arise transiently through reversible epigenetic changes (Sharma et al.,…”
Target identification using drug affinity responsive target stability (DARTS) (2009, background): “For instance, whereas unstable FRB domain and FKBP12 mutants are stabilized by the presence of ligands (6, 51) and topoisomerase-1 is destabilized by camptothecin (47), binding of estrogen receptor ligands each affects receptor stability differently (53).”
A chromatin-mediated reversible drug tolerant state in cancer cell subpopulations (2010, background): “, 2006), and has been implicated in cancer cell fates following drug exposure in culture (Cohen et al., 2008; Gascoigne and Taylor, 2008).”
Evolution of the cancer stem cell model. (2014, background): “Others have found that escape of cells from anticancer drug treatment involves a survival advantage conferred by cell-to-cell variability in the dynamics of speciﬁc proteins (Cohen et al., 2008).”
Large‐scale image‐based screening and profiling of cellular phenotypes (2017, background): “Large-scale FP tagging has been performed for hundreds to thousands of genes in the budding yeast Sacchramyces cerevisiae (2), the fruit fly Drosophila (8), and human cells (9).”