Kwok-kin Wong
Cancer Discovery · 2007–2018
A researcher in the Science corpus: 23 papers; trusts 1 researcher and is trusted by 0 researchers here, as inferred from the citation graph.
Whom Kwok-kin Wong trusts
Their strongest outbound trust, strongest first, inferred from their citations.
- Randy J. Read (in Computational Theory and Mathematics)
Papers from Kwok-kin Wong's perspective
Ordered by how strongly the researchers Kwok-kin Wong trusts endorse each paper. Same corpus, a different order for every researcher.
- EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy (Science)
- Anticancer drugs: To the rescue? (Nature reviews. Drug discovery)
- Refinement of macromolecular structures by the maximum-likelihood method.
- EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. (Proceedings of the National Academy of Sciences of the United States of America)
- KRAS Mutations and Primary Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib (PLoS Medicine)
- Targeting polo-like kinase 1 for cancer therapy (Nature Reviews. Cancer)
- Structure of the Epidermal Growth Factor Receptor Kinase Domain Alone and in Complex with a 4-Anilinoquinazoline Inhibitor* (Journal of Biological Chemistry)
- Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction (Cell)
- Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. (Cancer Cell)
- An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor. (Cell)
Their papers
- Effective Use of PI3K and MEK Inhibitors to Treat Mutant K-Ras G12D and PIK3CA H1047R Murine Lung Cancers (2008) — 1,344 citations
- A chromatin-mediated reversible drug tolerant state in cancer cell subpopulations (2010) — 2,613 citations
- A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. (2009) — 1,047 citations
- BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models (2008) — 1,413 citations
- Non-small-cell lung cancers: a heterogeneous set of diseases (2014) — 1,754 citations
- The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins (2013) — 1,381 citations
- The dTAG system for immediate and target-specific protein degradation (2018) — 886 citations
- SOX2 Is an Amplified Lineage Survival Oncogene in Lung and Esophageal Squamous Cell Carcinomas (2009) — 956 citations
- The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP (2008) — 2,013 citations
- mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis (2018) — 646 citations
- Novel mutant-selective EGFR kinase inhibitors against EGFR T790M (2009) — 979 citations
- PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib. (2007) — 708 citations
- EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation (2013) — 801 citations
- A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors (2011) — 620 citations
- STK11/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS-Mutant Lung Adenocarcinoma (2018) — 1,344 citations
- CDK4/6 Inhibition Augments Anti-Tumor Immunity by Enhancing T Cell Activation (2017) — 614 citations
- Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints (2016) — 1,425 citations
- Overcoming EGFR T790M and C797S resistance with mutant-selective allosteric inhibitors (2016) — 757 citations
- Co-occurring genomic alterations define major subsets of KRAS - mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities (2015) — 835 citations
- Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors (2013) — 1,183 citations