Specificities of heparan sulphate proteoglycans in developmental processes
By Norbert Perrimon, M. Bernfield. Nature, 2000
750 citations recorded by the source corpus.
Subfields: Cell Biology, Genetics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/71c2c77f0653fdda9f5853770366d2cbc9bda8e2
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In Cell Biology
In Genetics
In Molecular Biology
- C. Betsholtz
- E. Dejana
- Holger Gerhardt
- A. Ostman
- Meenhard Herlyn
- T. Bogenrieder
- Hans Clevers
- R. Nusse
Citations in the corpus
- Fringe is a glycosyltransferase that modifies Notch (2000, background): “Recent studies have identified several examples in which heparan sulphate proteoglycans have important roles in signal transduction pathway”
- Axis of evil: molecular mechanisms of cancer metastasis (2003, background): “…macromolecules, which play a key role in the selfassembly, insolubility, and barrier properties of basement membranes and extracellular matrices, as well as in the sequestration and stabilization of bioactive molecules (Perrimon and Bernfield, 2000; Iozzo, 2001; Perrimon and Bernfield, 2001).”
- Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall. (2003, background): “By binding to HSPGs, specific gradients of the GDFs may be created, which may guide or restrict morphogenetic responses (Perrimon and Bernfield 2000; Ruhrberg et al. 2002; Gerhardt et al. 2003).”
- The endothelial glycocalyx: composition, functions, and visualization (2007, background): “(2) Binding of plasma-derived molecules to the glycocalyx can lead to a local concentration gradient, which is often seen in growth factor-regulated gene transcription and developmental processes [61, 82].”
- Roles of heparan-sulphate glycosaminoglycans in cancer (2002, background): “Present at the cell–tissue–organ interface, they have been shown to have crucial regulatory roles in normal physiological processes, such as embroyogenesi”
- arrow encodes an LDL-receptor-related protein essential for Wingless signalling (2000, background): “Each of the mutants affecting this step, sugarless , sulfateless and dally , is substantially suppressed by providing excess Wg ligand, showing that glycosaminoglycans are not essential for reception of the signal but only increase the efficiency of ligand presentation to the receptor (ref”