Fringe is a glycosyltransferase that modifies Notch
By D. J. Moloney, V. Panin, S. H. Johnston, Jihua Chen, L. Shao, R. Wilson, Yang Wang, P. Stanley, Kenneth D. Irvine, R. Haltiwanger and 1 more. Nature, 2000
876 citations recorded by the source corpus.
Subfields: Biotechnology, Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/8b016e20ab155ea5099955b2b1633b7f88fb8ff3
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Citations in the corpus
- Delta signaling from the germ line controls the proliferation and differentiation of the somatic follicle cells during Drosophila oogenesis (2001, background): “A possible explanation for this difference in competence is that the stalk and polar cells express high levels of fringe, which encodes a glucosyltransferase that modifies Notch to make it more sensitive to Delta signaling (Bruckner et al. 2000; Jordan et al. 2000; Moloney et al. 2000; Munro and Fre”
- Glycomics hits the big time. (2010, positive): “The functions of many receptors are modulated by their glycans such as modulation of Notch receptors by the action of specific glycosyltransferases (Moloney et al., 2000), which regulate Notch's activation by its ligands, affecting many developmental events.”
- The Hes gene family: repressors and oscillators that orchestrate embryogenesis (2007, background): “One of its downstream target genes is the glycosyltransferase lunatic fringe (Lfng), which regulates Notch activity by glycosylation (Moloney et al., 2000; Brückner et al., 2000).”
- Fucose: biosynthesis and biological function in mammals. (2003, background): “O-fucose residues are also present on EGF domains of the mammalian Notch receptors (Moloney et al., 2000b), a family of transmembrane signaling proteins with important roles in cell fate determination during somite formation, neurogenesis, angiogenesis, and lymphoid development (Artavanis-Tsakonas…”
- Biological roles of glycans (2016, background): “An entirely new field opened up with the discovery that the Fringe molecule is a glycosyltransferase that modifies the important signaling protein Notch and thus modulates Notch–Delta interactions (182, 184).”
- Notch signaling: from the outside in. (2000, background): “However, removal f the CSL-binding site from the sim promoter is sufficient o induce ectopic sim expression pattern in a Notchndependent manner (Morel and Schweisguth, 2000).”