Triggering and modulation of apoptosis by oxidative stress.

By J. Chandra, Afshin Samali, S. Orrenius. Free Radical Biology & Medicine, 2000

1,364 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/718e63376aa3f647f14d7593bdbfc7878bedb7ba

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. A. Gorman
2. Afshin Samali

In Molecular Biology

1. J. F. Stevens
2. A. Gorman
3. Simone Fulda
4. Afshin Samali

Citations in the corpus

• Acrolein: sources, metabolism, and biomolecular interactions relevant to human health and disease. (2008, background): “Due to the spatially close histidine-residue, the cysteine sulfhydryl group is particularly reactive and, in turn, can be readily regulated by oxidative or nitrosative stress [135] or become inactivated by alkylation reactions with reactive electrophiles, such as acrolein.”
• Superoxide Flashes in Single Mitochondria (2008, neutral): “Increased oxidation or ROS bursts are implicated in hypoxia/reoxygenation injury and other stress perturbations including metabolic inhibition (Romashko et al., 1998) and proapoptotic stimulation ( Chandra et al., 2000 ).”
• Cellular Stress Responses: Cell Survival and Cell Death (2010, background): “For example, NO•-mediated inhibition of apoptosis in most cases is due to direct inhibition of caspase activity through S-nitrosylation of the active site cysteine conserved in all caspases although indirect effects on caspases can also be a component of toxicity in certain systems [214].”
• Melatonin: a well‐documented antioxidant with conditional pro‐oxidant actions (2014, background): “Free radicals promote cytochrome c release from mitochondria, activation of caspases, cell cycle control protein p53, and other apoptotic signaling proteins in a mitochondria-dependent or mitochondria-independent manner [34, 35].”
• Oxidative stress, DNA methylation and carcinogenesis. (2008, background): “ROS have also been shown to modulate the cell death (senescence) process [12] by acting either as an anti-senescence stimulus [13] or through”
• Non-commercial Research and Educational Use including without Limitation Use in Instruction at Your Institution, Sending It to Specific Colleagues That You Know, and Providing a Copy to Your Institution's Administrator. All Other Uses, Reproduction and Distribution, including without Limitation Comm (2005, neutral): “The orientational order of the molecule can be described by the S-parameters S xx , S zz and S yz .”