Get a ligand, get a life: integrins, signaling and cell survival

By D. Stupack, D. Cheresh. Journal of Cell Science, 2002

614 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology and Allergy, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/706fc525d2dc9ab2d23dc7178014c90ee348340f

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Citations in the corpus

Tumor angiogenesis: molecular pathways and therapeutic targets (2011, background): “A cell in an inappropriate environment may express unligated integrin, which can actively promote apoptosis, anoikis or integrin-mediated deat”
Molecular regulation of vessel maturation (2003, background): “Paradoxically, unlike the pharmacologic interventions, the disruption of genes encoding α v β 3 and α v β 5 (integrin receptors for fibronectin, vitronectin, fibrinogen, osteopontin, thrombospondin, endostatin and von Willebrand factor) does not block angiogenesi”
Axis of evil: molecular mechanisms of cancer metastasis (2003, background): “Moreover, these downstream effector molecules in return have repercussions on the expression and function of cell surface molecules (‘inside-out’ signaling) (Hood and Cheresh, 2002; Stupack and Cheresh, 2002).”
To move or not to move? (2004, background): “Moreover, as integrin signalling is required for cell survival and proliferation (Stupack & Cheresh, 2002), its sustained inhibition might account for the reduced growth and apoptotic events that are observed in semaphorin-treated cells (for example, see Tomizawa et al, 2001).”
Formation and function of the myofibroblast during tissue repair. (2007, background): “The intracellular pathways linking stress release to induction of apoptosis are unclear but likely involve cell matrix junctions (Stupack and Cheresh, 2002; Reddig and Juliano, 2005), that is to say stress perception mechanisms similar to those used to control fibroblast-to-myofibroblast transition.”
Galectin-1: a small protein with major functions. (2006, background): “The activity of integrin adhesion receptors is essential for normal cellular function and survival (Frisch and Ruoslahti, 1997; Stupack and Cheresch, 2002).”