MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation

By Yvonne Tay, Jinqiu Zhang, A. Thomson, Bing Lim, Isidore Rigoutsos. Nature, 2008

1,368 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7017fc4a1bdd3a51a38b570d1c3b3db9927fbe88

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. John S. Mattick
2. Marcel E. Dinger
3. George A. Calin
4. Tim R. Mercer
5. Artemis G. Hatzigeorgiou
6. Richard I. Gregory
7. Jianhua Yang
8. Yvonne Tay

In Molecular Biology

1. John S. Mattick
2. David P. Bartel
3. Marcel E. Dinger
4. George A. Calin
5. Olivier Voinnet
6. Tim R. Mercer
7. Yvonne Tay
8. P. Pandolfi

Citations in the corpus

• Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function (2015, background): “Accumulating evidence has shown that miRNAs can stably exist in body fluids, including saliva [11,12], urine [13], breast milk [14], and blood [11,15,16].”
• Desperately seeking microRNA targets (2010, background): “Recent studies provide examples of MREs located outside of the 3′ UTR (especially in the coding sequence (CDS)) or that lack exact seed pairing, but compensate by downstream complementarit”
• Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs (2011, positive): “MicroRNA target validation assays were performed as described previously (Tay et al., 2008).”
• DIANA-microT web server v5.0: service integration into miRNA functional analysis workflows (2013, background): “However, accumulated experimental evidence has revealed that miRNA-binding sites within coding sequences are also functional in controlling gene expression (11).”
• starBase: a database for exploring microRNA–mRNA interaction maps from Argonaute CLIP-Seq and Degradome-Seq data (2010, background): “…numerous CLIP-Seq clusters were not located within the 3 0 -UTR of the gene, indicating that the miRNA may bind to the coding region and the 5 0 -UTR, as has been reported for ribosomal protein regulation by mir-10a (48) and Nanog, Oct4 and Sox2 regulation by miR-134, miR-296 and miR-470 (49).”
• miRNA‐dependent gene silencing involving Ago2‐mediated cleavage of a circular antisense RNA (2011, background): “…cleavage of mRNAs with near perfect complementary miRNA target sites in an RNA interference (RNAi)-like manner (Hutvagner and Zamore, 2002; Yekta et al, 2004), and certain miRNAs may function by targeting sites in the 50 UTR and ORF of mRNAs (Forman et al, 2008; Orom et al, 2008; Tay et al, 2008).”
• Identifying miRNAs, targets and functions (2012, background): “Mature miRNAs can alter the expression of genes by binding to the 50-UTR [71, 72].”
• Non-coding RNAs in disease: from mechanisms to therapeutics (2023, positive): “For example, CDS-located miRNA interaction sites (miR-134, miR-296 and miR-470) in Nanog, Oct4 and Sox2 modulate embryonic stem cell differentiation 32 .”
• MicroRNAs: Processing, Maturation, Target Recognition and Regulatory Functions. (2011, background): “However, subsequent studies revealed that functional MREs may also occur in the 5' UTR (62–64) as well as in the coding sequence (65).”
• Biological functions of microRNAs: a review (2011, background): “To directly demonstrate this function for miR-7, the network was subjected to temperature fluctuation; it was found that miR-7 is essential for the maintenance of regulatory stability under conditions of environmental flux, suggesting that some conserved miRNAs like miR-7 may enter into novel geneti”