The regulation and function of Class III PI3Ks: novel roles for Vps34.

By J. Backer. Biochemical Journal, 2008

672 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6f5e6e2a7a035b8e29af6b6f9217b6c1a669f45c

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In Cell Biology

1. Young Chul Kim
2. H. Park
3. K. Guan
4. Joungmok Kim
5. Padinjat Raghu
6. J. Clarke
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In Epidemiology

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2. K. Guan
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4. Joungmok Kim
5. J. Clarke
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In Molecular Biology

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4. Arkaitz Carracedo
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6. P. Pandolfi
7. R. Russell
8. H. Park

Citations in the corpus

• mTOR regulation of autophagy (2010, background): “Alternatively, it could be due to the involvement of hVps34 into multiple different complexes [33].”
• Autophagy and autophagy-related proteins in cancer (2020, background): “The sole Class III PI3K, Vps34, is associated with the protein kinase Vps15, which functions as a Vps34 regulatory subunit [112].”
• Phosphatidylinositol 5-phosphate 4-kinase (PIP4K) regulates TOR signaling and cell growth during Drosophila development (2013, methodology): “In vitro, PIP4K enzymes can phosphorylate both PI5P and PI3P to produce PI(4,5)P2 and PI(3,4)P2, respectively (8, 9).”
• ULK1 induces autophagy by phosphorylating Beclin-1 and activating Vps34 lipid kinase (2013, methodology): “Active GST-ULK1 (1-649) and GST-ULK2 (1-478) from insect cells was purchased from CQuential Solutions (Moraga, CA).”
• Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy (2013, background): “The mammalian Vps34 also exists in different complexes and is involved in a variety of cellular functions, such asmultivesicular body pathway, retrograde trafficking from endosomes to the Golgi, phagosome maturation, and autophagy (Backer, 2008).”
• Milk Protein Synthesis in the Lactating Mammary Gland: Insights from Transcriptomics Analyses (2012, neutral): “mechanisms [153, 159, 160].”
• Phosphoinositides: tiny lipids with giant impact on cell regulation. (2013, background): “Vps34p not only regulates the trafficking of proteins to the vacuole but is also important for autophagy (74, 751), a starvation-induced protein-degradation process targeting cytosol and organelles to the lysosome (1073).”
• The PTEN–PI3K pathway: of feedbacks and cross-talks (2008, background): “Beck SE, Carethers JM. (2007). BMP suppresses PTEN expression via”
• The emerging mechanisms of isoform-specific PI3K signalling (2010, background): “Yeast with a homozygous deletion of Vps34 are viable but show growth defects under non-stressed and stressed conditions, and defects in vacuolar protein sortin”
• Targeting the phosphoinositide 3-kinase (PI3K) pathway in cancer (2009, background): “VPS34 has been shown to function as a nutrient-regulated lipid kinase that mediates signalling through mammalian target of rapamycin ( mTOR ), indicating a potential role in regulating cell growt”