Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor–κB and IκBα kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of…

By A. Bharti, N. Donato, Sujay K. Singh, Bharat B. Aggarwal. 2003

685 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/6e73a5bda7dadb3f62aa7ecbb38fa5f8d01b4aa9

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In Cancer Research

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Citations in the corpus

Molecular targets of dietary agents for prevention and therapy of cancer. (2006, background): “[65] Bharti AC, Donato N, Singh S, Aggarwal BB.”
Targets of curcumin (2011, background): “In mantle cell lymphoma and multiple myeloma cell lines, curcumin activated caspase-7/9, and induced PARP cleavage [222,223].”
Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma (2011, background): “Curcumin has been shown to suppress the activation of NF- B, an inducible transcription factor that regulates the expression of a host of genes involved in inflammation, cellular proliferation and cell survival [32-57].”
Curcumin: An Anti-Inflammatory Molecule from a Curry Spice on the Path to Cancer Treatment (2011, background): “Suppression of the inflammatory response by curcumin as discussed in the preclinical studies involves inhibition of the induction of COX-1, COX-2, iNOS, and production of cytokines such as interferon-γ [90,106].”
Is NF-κB a good target for cancer therapy? Hopes and pitfalls (2009, background): “Constitutive nuclear NF-κB activity has been described in many human multiple myeloma cell lines and primary myeloma cell”
Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals (2010, background): “phosphorylation in human multiple myeloma cells [32] and murine melanoma cells [33] through suppression of IKK activity, which contributed to its antiproliferative, proapoptotic, and antimetastatic activities.”
Potential Therapeutic Effects of Curcumin, the Anti-inflammatory Agent, Against Neurodegenerative, Cardiovascular, Pulmonary, Metabolic, Autoimmune and Neoplastic Diseases (2008, background): “Our laboratory was the first to demonstrate that curcumin is a potent inhibitor of STAT 3, another transcription factor through which proinflammatory cytokine IL-6 mediates its effects (Bharti et al., 2003a).”