Microglial activation‐mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease

By Hui-Ming Gao, J. Jiang, B. Wilson, Wanqin Zhang, Jau-Shyong Hong, B. Liu. Journal of Neurochemistry, 2002

690 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/6dbe9b8315f1cc39a48ef390f0c43a5398479f06

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. M. Block
2. Jau-Shyong Hong
3. M. Tansey
4. M. Goldberg
5. P. Whitton
6. Fulton Crews
7. Charles L Raison
8. L. Capuron

In Neurology

1. M. Block
2. Jau-Shyong Hong
3. P. Whitton
4. M. Tansey
5. M. Goldberg
6. Melinda E Lull
7. Bin Liu
8. Charles L Raison

Citations in the corpus

• Role of Microglia in Inflammation-Mediated Neurodegenerative Diseases: Mechanisms and Strategies for Therapeutic Intervention (2003, methodology): “To test this hypothesis, an inflammation-mediated rat model of PD was established in our laboratory by supranigral and continuous infusion of nanogram quantities of an inflammogen (LPS) for 2 weeks (Gao et al., 2002b).”
• Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior (2012, background): “…decrease in tyrosine hydroxylase-expressing neurons in the substantia nigra after 10 months (Qin et al, 2007), and chronic administration of high-dose endotoxin (2 weeks at 5 ng/h) into the brain was associated with a 70% reduction of nigral dopaminergic neurons within 10 weeks (Gao et al, 2002).”
• Cytokines sing the blues: inflammation and the pathogenesis of depression. (2006, background): “Consistent with the pathophysiology of depression, these cytokine-induced behavioral changes are associated with alterations in the metabolism of serotonin, norepinephrine and dopamine in brain regions essential to the regulation of emotion, including the limbic system (amygdala, hippocampus and nuc”
• Epidemiology and etiology of Parkinson’s disease: a review of the evidence (2011, background): “In rats, chronic infusion of bacterial endotoxin lipopolysacharide (LPS) into substantia nigra resulted in activation of microglia followed by degeneration of dopaminergic neurons [555], suggesting that inflammation may precede neurodegeneration.”
• Progress Towards Biocompatible Intracortical Microelectrodes for Neural Interfacing Applications (2014, neutral): “[125–127].”
• Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration (2007, background): “Further, LPS activation of microglia both in vivo and in vitro causes the progressive and cumulative loss of DA neurons over time (Gao et al., 2002; Ling et al., 2002, 2006).”
• Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. (2005, background): “Infusion of LPS induced a delayed, progressive, and selective loss of nigral DA neurons (Gao et al., 2002b).”
• Microglial Activation & Chronic Neurodegeneration (2010, background): “in vitro causing the progressive and cumulative loss of DA neurons with time.(129,169,170) Although traditionally”
• Inflammation as a causative factor in the aetiology of Parkinson's disease (2007, background): “mation, MPTP-induced neurotoxicity is linked to microglial activation (Gao et al., 2002b; McGeer et al., 2003).”
• Neuroinflammation in Parkinson’s disease: its role in neuronal death and implications for therapeutic intervention (2009, background): “N IH -PA Author M anuscript N IH -PA Author M anuscript N IH -PA Author M anuscript Gao et al., 2002; Gao et al., 2003; Gao et al., 2008).”