Role of Microglia in Inflammation-Mediated Neurodegenerative Diseases: Mechanisms and Strategies for Therapeutic Intervention

By Bin Liu, Jau-Shyong Hong. Journal of Pharmacology and Experimental Therapeutics, 2003

1,138 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Complementary and alternative medicine, Neurology

View Paper: https://www.semanticscholar.org/paper/64978ac2e8ac04a6b7d092bed6da65b6dd0b9054

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. M. Block
2. Jau-Shyong Hong
3. P. Mcgeer
4. E. Mcgeer
5. M. O’Banion
6. Michael T. Heneka
7. M. Goldberg
8. M. Tansey

In Complementary and alternative medicine

1. M. Block
2. P. Mcgeer
3. E. Mcgeer
4. Jau-Shyong Hong

In Neurology

1. M. Block
2. Jau-Shyong Hong
3. M. Tansey
4. M. Goldberg
5. P. Mcgeer
6. E. Mcgeer
7. M. O’Banion
8. J. Suttles

Citations in the corpus

• Tumor Necrosis Factor Alpha: A Link between Neuroinflammation and Excitotoxicity (2014, neutral): “Thus, microglia can be activated to release TNF-α at early asymptomatic disease stages by sensing the earliest neuronal stress and later, infiltrated T cells releasing IFN-γwould keep microglia in an active state [64, 65].”
• Inflammatory processes in Alzheimer's disease. (2007, background): “Finally, microglia can also secrete several trophic factors, such as the glia-derived neurotrophic factor (GDNF), which exert a well documented neuroprotective function (Liu and Hong, 2003).”
• Neuroinflammation in Alzheimer's disease: Current evidence and future directions (2016, background): “These cells can remain for a long time in the activated phenotype, releasing cytokines, and neurotoxic agents that can worsen CNS damage [5].”
• Inflammation and neurodegeneration in Parkinson's disease. (2004, result): “The large number of recent reviews on the subject bears witness to the growing realization of the possible importance of this inflammatory response to PD progression [2–7], a hypothesis receiving strong support from the recent epidemiological report that chronic use of nonsteroidal antiinflammatory ”
• Aggregated α‐synuclein activates microglia: a process leading to disease progression in Parkinson's disease (2005, background): “Once activated, microglia display conspicuous functional plasticity and ultimately transform into a macrophage-like phenotype that involves morphological changes, proliferation, increased expression of cell surface receptors and the production of neurotrophic factors and neurotoxic factors, e.g., re”
• Functional plasticity of macrophages: reversible adaptation to changing microenvironments (2004, background): “Each population is fully capable of changing its functional pattern, as evidenced by the response to infectious or inflammatory insult [2, 3, 22].”
• Glycogen Synthase Kinase-3 (GSK3): Inflammation, Diseases, and Therapeutics (2007, background): “trocytes and microglia are not thought to be entirely detrimental in AD [113, 114].”
• Neuroinflammation in Parkinson’s disease: its role in neuronal death and implications for therapeutic intervention (2009, background): “…as well as the non-immunosuppressant derivatives of FK-506 referred to as immunophilin ligands including pentoxifylline (Wersinger and Sidhu, 2002; Liu and Hong, 2003), and the nonselective COX-2 inhibitor sodium salicylate have all shown neuroprotective activity in either MPTP-induced nigral…”