Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins.
By A. Verhagen, P. Ekert, M. Pakusch, J. Silke, L. Connolly, G. E. Reid, Rob Moritz, Richard J. Simpson, David L. Vaux. Cell, 2000
2,500 citations recorded by the source corpus.
Subfields: Endocrinology, Diabetes and Metabolism, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/6d72b6b1b3931845a4b6fe6f1fe98fbc645aa698
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In Endocrinology, Diabetes and Metabolism
In Molecular Biology
- Jerry M. Adams
- Douglas R. Green
- Simone Fulda
- Suzanne Cory
- Guido Kroemer
- Yigong Shi
- G. Salvesen
- D. Vučić
Citations in the corpus
- Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. (2009, background): “Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-a”
- Apoptosis in development (2000, background): “Whether or not RPR, GRIM and HID have any direct homologues in mammals, they nonetheless interact with components of Drosophila cell death machinery that are conserved, in particular the evolutionarily conserved inhibitor-of-apoptosis protein (IAP) family that in mammals are targets of the pro-”
- The expanding role of mitochondria in apoptosis. (2001, background): “Concurrent with cytochrome c, Smac/Diablo, a 25-kD mitochondrial protein, is released from mitochondria into the cytosol during apoptosis (Du et al. 2000; Verhagen et al. 2000).”
- Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. (2005, background): “…well be the major partner of Mcl-1 in healthy cells, because in a large-scale coimmunoprecipitation experiment that used well-established methods (Verhagen et al. 2000) to isolate Mcl-1-interacting partners and identify them by mass spectroscopy, Bak was the only associated family member found…”
- Is NF-κB a good target for cancer therapy? Hopes and pitfalls (2009, background): “The anti-apoptotic activity of IAPs is counteracted by the natural mammalian IAP antagonist SMAC/DIABLO (second mitochondrial activator of caspases/direct IAP binding protein with low pI), which is released from mitochondria into the cytoplasm upon apoptosis inductio”