Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis.

By M. Arita, Masaru Yoshida, Song Hong, Eric Tjonahen, J. Glickman, N. Petasis, R. Blumberg, C. Serhan. Proceedings of the National Academy of Sciences of the United States of America, 2005

628 citations recorded by the source corpus.

Resolvin E1 (RvE1; 5S,12R,18R-trihydroxyeicosapentaenoic acid) is an antiinflammatory lipid mediator derived from omega-3 fatty acid eicosapentaenoic acid (EPA). At the local site of inflammation, aspirin treatment enhances EPA conversion to 18R-oxygenated products, including RvE1, which carry potent antiinflammatory signals. Here, we obtained evidence for reduced leukocyte infiltration in a mouse peritonitis model, where the administration of EPA and aspirin initiated the generation of RvE1 in the exudates. Similar results were obtained with the administration of synthetic RvE1, which blocked leukocyte infiltration. RvE1 also protected against the development of 2,4,6-trinitrobenzene sulfonic acid-induced colitis. The beneficial effect was reflected by increased survival rates, sustained body weight, improvement of histologic scores, reduced serum anti-2,4,6-trinitrobenzene sulfonic acid IgG, decreased leukocyte infiltration, and proinflammatory gene expression, including IL-12 p40, TNF-alpha, and inducible nitric oxide synthase. Thus, the endogenous lipid mediator RvE1 counter-regulates leukocyte-mediated tissue injury and proinflammatory gene expression. These findings show an endogenous mechanism that may underlie the beneficial actions of omega-3 EPA and provide targeted approaches for the treatment of intestinal inflammation.

Subfields: Biochemistry, Immunology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/6d3b1c75334a19fbac0df74211ee687b93765d5e

How researchers see this paper

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In Biochemistry

1. P. Calder
2. C. Serhan
3. Chia Nan
4. Emily Y. Chew
5. J. Sangiovanni
6. B. Levy
7. D. Mozaffarian
8. I. Djuricić

In Immunology

1. P. Calder
2. C. Serhan
3. Chia Nan
4. B. Levy

In Nutrition and Dietetics

1. P. Calder
2. C. Serhan
3. Chia Nan
4. Emily Y. Chew
5. J. Sangiovanni
6. M. Arita
7. B. Levy
8. D. Mozaffarian

Citations in the corpus

• Resolvin E1 Selectively Interacts with Leukotriene B4 Receptor BLT1 and ChemR23 to Regulate Inflammation1 (2007, background): “omega-3 EPA that are enhanced with aspirin therapy (8, 9).”
• Omega-3 fatty acids and inflammatory processes: from molecules to man. (2017, positive): “reduce inflammation and protect experimental animals in models of inflammatory disease including arthritis [54], colitis [55] and asthma [56-59].”
• Increased dietary intake of ω-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis (2007, background): “Furthermore, the metabolites NPD1, RvD1 and RvE1 dose-dependently reduce Tnf mRNA expression in macrophages in culture and in other inflammatory model”