Resolvin E1 Selectively Interacts with Leukotriene B4 Receptor BLT1 and ChemR23 to Regulate Inflammation1

By M. Arita, T. Ohira, Yee-Ping Sun, S. Elangovan, Chia Nan, C. Serhan. Journal of Immunology, 2007

632 citations recorded by the source corpus.

Subfields: Biochemistry, Clinical Biochemistry, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/00ed428c37d7b0f148ee87e30e2a03c80ece6606

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. C. Serhan
2. B. Levy
3. N. Petasis
4. N. Borregaard
5. Chia Nan
6. Rong Yang
7. P. Calder
8. D. Mozaffarian

In Clinical Biochemistry

1. P. Kubes

In Nutrition and Dietetics

1. C. Serhan
2. B. Levy
3. N. Borregaard
4. N. Petasis
5. Chia Nan
6. Rong Yang
7. J. Tschopp
8. P. Calder

Citations in the corpus

• Resolution of inflammation: an integrated view (2013, neutral): “…macrophages, LXA4 also promotes non-phlogistic phagocytosis of apoptotic neutrophils with reduced release of CXCL8 (Jozsef et al, 2002) monocytes, macrophages and dendritic cells to attenuate TNF-mediated NF k B activation, thus forming an anti-inflammatory signalling pathway (Arita et al, 2007).”
• Neutrophils, from marrow to microbes. (2010, background): “, 1995), and most newly formed lysozyme is spilled out of the cells, while a-defensins are efficiently withheld when formed in promyelocytes, but largely spilled out when formed in the more mature myelocytes, indicating that some selectivity does exist in the routing between constitutive secretion a”
• Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines (2018, background): “The common mechanism by which this occurs appears to be through suppression of the NF-κB activation in a partly PPARγ-dependent manner, with associated downstream signaling and alteration in transcriptomics pathways (30, 31).”
• Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators. (2018, background): “This antagonism is exemplified by inhibition of interactions of LTB 4 with its receptor BLT1 by RvE1 and MaR1 (110, 111).”
• The Neutrophil's Role During Health and Disease. (2019, background): “For example, the resolvin E1 binds to the leukotriene B4 receptor (BLT1) on neutrophils and prevents stimulation by leukotriene B4 (16).”
• Resolvin D1 binds human phagocytes with evidence for proresolving receptors (2010, background): “RvE1 stimulates proresolution pathways via ChemR23, which is abundantly expressed in MΦ and dendritic cells (10), whereas it binds to BLT1 for its anti-PMN actions (11).”
• Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. (2013, background): “years, some enzymatic oxygenated products generated from u-3 FAs have been shown to exert anti-inflammatory activity and contribute functionally to the resolution of inflammation (Arita et al., 2007; Serhan et al., 2002; Spite et al., 2009).”