Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

By Mitsuhiro Watanabe, Sander M. Houten, C. Mataki, M. Christoffolete, Brian W Kim, Hiroyuki Sato, N. Messaddeq, J. Harney, O. Ezaki, T. Kodama and 3 more. Nature, 2006

2,173 citations recorded by the source corpus.

Subfields: Genetics, Oncology, Surgery

View Paper: https://www.semanticscholar.org/paper/6ce11276d8b6afecf254ca4431bef7a2428d121e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Ian A. Wilson
2. Jianping Ye
3. Jeremy K. Nicholson
4. J. Zierath
5. B. Spiegelman
6. G. Brent
7. Edward C. Holmes

In Oncology

1. J. Y. Chiang
2. Johan Auwerx
3. C. Cantó
4. P. Edwards
5. N. Lee
6. B. Spiegelman
7. G. Karsenty
8. P. Ducy

In Surgery

1. J. Y. Chiang
2. G. Svegliati-Baroni
3. C. Cantó
4. Jianping Ye
5. P. Edwards
6. J. Zierath
7. Bart Staels
8. C. R. Kahn

Citations in the corpus

• Role of bile acids and bile acid receptors in metabolic regulation. (2009, background): “Indeed, FXR activation increases apoC-II expression (146), an activator of lipoprotein lipase (LPL) activity and decreases both apoCIII (49) and ANGPTL3 (342), which are LPL inhibitors.”
• Bile Acid Signaling in Metabolic Disease and Drug Therapy (2014, neutral): “2% cholesterol) prevented diet-induced weight gain (Watanabe et al., 2006).”
• Fibroblast growth factor 21 corrects obesity in mice. (2008, background): “Taking into account a recent concept on bile acids serving as energy expenditure regulators via D2 activation (24), the potential for FGF21/ Klotho to modulate bile acid synthesis (22) (Table 1) as well as FGF21 effects on energy expenditure seen in this study (Fig.”
• Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome. (2016, methodology): “5% w/w cholic acid (CA) has been previously reported (Watanabe et al., 2006; Watanabe et al., 2004).”
• Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice (2009, background): “Several natural products, such as resveratrol (1; 2), bile acid (3), and genipin (4), have been reported to incresae thermogenic activities in animal or cellular models.”
• Deiodinases: implications of the local control of thyroid hormone action. (2006, neutral): “Another potential site where the bile acid/GPBAR1/D2 pathway may affect energy expenditure in adults is in skeletal muscle, and the pathway has been shown to be operant in human skeletal myocytes in culture (29).”
• Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle (2010, methodology): “Oxygen consumption was measured using the XF24 equipment (Seahorse Bioscience Inc., North Billerica, MA) as described (Watanabe et al., 2006).”
• Cancer cachexia: understanding the molecular basis (2014, neutral): “(AgRP(83-132)) prevents cachexia-related symptoms”
• Gut Microbiota in Cardiovascular Health and Disease (2017, background): “well as glucose metabolism, through FXR and GPR131.(17,18,44) In addition, some of the proatherogenic effects of TMAO are linked to reduction in reverse cholesterol transport, alteration in tissue cholesterol and sterol metabolism, and changes in BA composition, pool size, and transport in both the ”
• Lipotoxicity and the gut-liver axis in NASH pathogenesis. (2018, background): “reduction associated with enhanced energy expenditure and was found to be mediated by a TGR5cAMP pathway in brown adipose tissue and skeletal muscle [154].”
• Guidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement (2014, neutral): “In vitro data and rodent studies have established that primary changes in D2 or D3 in a given tissue can lead to tissue-specific changes in thyroid status without affecting circulating T3, T4, or TSH (362,363); human studies have not been reported.”
• Bile acids: regulation of synthesis (2009, background): “of cAMP, which induces iodothyrone deiodinase (D2) and production of thyroid hormone T3 leading to stimulation of energy metabolism and improving glucose tolerance and insulin sensitivity (10, 12, 37).”