Geriatric muscle stem cells switch reversible quiescence into senescence

By Pedro Sousa‐Victor, Susana Gutarra, Laura Garcia-Prat, J. Rodríguez-Ubreva, L. Ortet, Vanessa Ruiz-Bonilla, M. Jardí, Esteban Ballestar, S. González, A. Serrano and 2 more. Nature, 2014

896 citations recorded by the source corpus.

Subfields: Aging, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/5594037b999265d08c8d741425e80cf0f2fdd027

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. E. Verdin
2. Adam Freund
3. Jesús Gil
4. J. Campisi
5. Domhnall McHugh
6. Y. Fouad
7. C. Aanei

In Molecular Biology

1. Jesús Gil
2. J. Campisi
3. Adam Freund
4. E. Verdin
5. Domhnall McHugh
6. M. Demaria
7. F. d’Adda di Fagagna

In Physiology

1. Jesús Gil
2. Adam Freund
3. J. Campisi
4. E. Verdin
5. Domhnall McHugh
6. Su Liu
7. M. Demaria
8. P. Jat

Citations in the corpus

• In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming (2016, neutral): “…aging and as a consequence of environmental and cell-intrinsic factors, there is a decrease in the number and functionality of satellite cells that switch from a quiescent to a pre-senescence state that hampers their regenerative capacity (Garcı´a-Prat et al., 2016; Sousa-Victor et al., 2014).”
• Satellite Cells and Skeletal Muscle Regeneration (2015, neutral): “Loss of reversible quiescence in aged satellite cells is accompanied by derepression of the CKI Cdkn2a (285).”
• Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype (2015, background): “The permanent growth arrest can deplete progenitor or stem cell pools, thereby compromising tissue repair and regeneration (Kuilman et al., 2010; Sousa-Victor et al., 2014; Velarde et al., 2015).”
• Senescence and aging: Causes, consequences, and therapeutic avenues (2018, background): “However, with age, they become senescent, up-regulating p16INK4a (Sousa-Victor et al., 2014).”