Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs

By Christopher J. H. Porter, Natalie L. Trevaskis, W. Charman. Nature reviews. Drug discovery, 2007

1,769 citations recorded by the source corpus.

Subfields: Oncology, Pharmaceutical Science, Surgery

View Paper: https://www.semanticscholar.org/paper/6c5dbe17186c003a002695539c39da0df3d1f720

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Oncology

1. D. McClements
2. Jiajia Rao
3. J. Dressman
4. Colin W. Pouton
5. Amin Rostami-Hodjegan
6. Masoud Jamei

In Pharmaceutical Science

1. D. McClements
2. Jiajia Rao
3. Christopher J. H. Porter
4. W. Charman
5. Natalie L. Trevaskis
6. Colin W. Pouton
7. S. Charman
8. H. Williams

In Surgery

1. M. Bergstrand

Citations in the corpus

• Food-Grade Nanoemulsions: Formulation, Fabrication, Properties, Performance, Biological Fate, and Potential Toxicity (2011, background): “Lipid digestion also depends on the molecular characteristics of digestible triacylglycerols oils, eg, medium-chain triglycerides (MCT) tend to be digested more rapidly than long-chain triglycerides (corn oil) ( Porter et al, 2007 ).”
• Strategies to Address Low Drug Solubility in Discovery and Development (2013, methodology): “Lymphatic drug transport has been described for many highly lipophilic drugs and has been the subject of several reviews (Porter and Charman, 2001b; O’Driscoll, 2002; Porter et al., 2007; Trevaskis et al., 2008; Yanez et al., 2011).”
• Dissolution Media Simulating Conditions in the Proximal Human Gastrointestinal Tract: An Update (2008, methodology): “(27) were applied to generate compositions of biorelevant media more representative of the fasted and fed conditions in”
• Nanoemulsion: Concepts, development and applications in drug delivery (2017, background): “Drugs which enter mesenteric lymph are directly transported to systemic circulation without undergoing hepatic first pass metabolism[92].”
• PBPK models for the prediction of in vivo performance of oral dosage forms. (2014, methodology): “SolBiorel Solaq ScaqxMWt ¼ SRxCbile ð4Þ Bile salt concentrations in individual gut compartments in fasted and fed state can be calculated based on published values for human, rat, and dog (Porter et al., 2007; Sugano, 2009a).”